Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil.
Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.
Virol J. 2018 Jan 25;15(1):23. doi: 10.1186/s12985-018-0938-2.
Zika virus is an emerging arbovirus of the family Flaviviridae and genus Flavivirus that until 2007 was restricted to a few cases of mild illness in Africa and Asia.
We report a case of atrial fibrillation disclosed during an acute Zika virus infection in a 49-year-old man. Different biological samples were analyzed for the molecular diagnosis of Zika by real-time PCR, however only the saliva specimen was positive. The patient's wife tested positive in the serum sample, although she was an asymptomatic carrier. Moreover, a complete overview of patient's biomarkers, including cytokines, chemokines, and growth-factors levels, was analyzed and compared to gender and age matching non-infected controls, as well as other Zika infected patients, considering the 95%CI of the mean values. Elevated levels of CXCL8, CCL11, CCL2, CXCL10, IL-1β, IL-6, TNF-α, IFN-γ, IL-17, IL-1Ra, IL-4, IL-9, FGF-basic, PDGF, G-CSF, and GM-CSF were observed in the Atrial fibrillation patient, in contrast to uninfected controls. Furthermore, increased levels of CCL5, IL-1β, TNF-α, IFN-γ, IL-9, G-CSF, and GM-CSF were observed only in the atrial fibrillation patient, when compared to other Zika patients.
To our knowledge, this is the first description of this type of cardiac disorder in Zika patients which may be considered another atypical manifestation during Zika virus infection.
寨卡病毒是黄病毒科黄病毒属的一种新兴虫媒病毒，直到 2007 年，它只在非洲和亚洲的少数几例轻度疾病中被发现。
我们报告了一例 49 岁男性急性寨卡病毒感染并发心房颤动的病例。通过实时 PCR 对不同的生物样本进行了寨卡病毒的分子诊断分析，但只有唾液标本呈阳性。患者的妻子在血清样本中呈阳性，尽管她是无症状携带者。此外，还分析并比较了患者的生物标志物（包括细胞因子、趋化因子和生长因子水平）的全貌，与性别和年龄匹配的未感染对照以及其他寨卡病毒感染患者进行了比较，同时考虑了平均值的 95%置信区间。与未感染对照相比，心房颤动患者的 CXCL8、CCL11、CCL2、CXCL10、IL-1β、IL-6、TNF-α、IFN-γ、IL-17、IL-1Ra、IL-4、IL-9、FGF-basic、PDGF、G-CSF 和 GM-CSF 水平升高。此外，与其他寨卡病毒患者相比，仅在心房颤动患者中观察到 CCL5、IL-1β、TNF-α、IFN-γ、IL-9、G-CSF 和 GM-CSF 水平升高。
据我们所知，这是首例描述此类心脏疾病在寨卡病毒患者中的发生情况，这可能被视为寨卡病毒感染期间的另一种非典型表现。
