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鸡溶菌酶基因的编码序列和间隔序列的排列

Arrangement of coding and intervening sequences of chicken lysozyme gene.

作者信息

Lindenmaier W, Nguyen-Huu M C, Lurz R, Stratmann M, Blin N, Wurtz T, Hauser H J, Sippel A E, Schütz G

出版信息

Proc Natl Acad Sci U S A. 1979 Dec;76(12):6196-200. doi: 10.1073/pnas.76.12.6196.

DOI:10.1073/pnas.76.12.6196
PMID:293713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411830/
Abstract

Hybrid phages that contain chicken lysozyme gene sequences have been isolated from a chicken DNA library. Two overlapping clones covering a region of 22 kilobase pairs around this gene have been studied by restriction mapping. Southern hybridization, and electron microscopic analysis of hybrids between lysozyme mRNA and the cloned cellular DNA. Three intervening sequences interrupt the lysozyme structural gene. The cellular gene is at least 3.9 kilobases long, about 6 times the length of the structural gene.

摘要

已从鸡DNA文库中分离出含有鸡溶菌酶基因序列的杂种噬菌体。通过限制性酶切图谱分析、Southern杂交以及溶菌酶mRNA与克隆的细胞DNA之间杂种的电子显微镜分析，对覆盖该基因周围22千碱基对区域的两个重叠克隆进行了研究。三个间隔序列中断了溶菌酶结构基因。细胞基因至少长3.9千碱基，约为结构基因长度的6倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/42b9fafcb35f/pnas00012-0183-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/95eb71fa25ab/pnas00012-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/717c9f14891e/pnas00012-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/c765dc81c502/pnas00012-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/70360f8abdc9/pnas00012-0183-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/42b9fafcb35f/pnas00012-0183-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/95eb71fa25ab/pnas00012-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/717c9f14891e/pnas00012-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/c765dc81c502/pnas00012-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/70360f8abdc9/pnas00012-0183-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc77/411830/42b9fafcb35f/pnas00012-0183-c.jpg

相似文献

1
Arrangement of coding and intervening sequences of chicken lysozyme gene.鸡溶菌酶基因的编码序列和间隔序列的排列
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6196-200. doi: 10.1073/pnas.76.12.6196.
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引用本文的文献

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The developmental activation of the chicken lysozyme locus in transgenic mice requires the interaction of a subset of enhancer elements with the promoter.转基因小鼠中鸡溶菌酶基因座的发育激活需要增强子元件的一个子集与启动子相互作用。
Nucleic Acids Res. 1997 Aug 1;25(15):2992-3000. doi: 10.1093/nar/25.15.2992.
2
Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice.转基因小鼠中鸡溶菌酶基因结构域上定位控制功能的剖析。
Nucleic Acids Res. 1994 Oct 11;22(20):4202-10. doi: 10.1093/nar/22.20.4202.
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Mechanisms by which eucaryotic genes evolve.

本文引用的文献

1
Quantitative measurement of ovalbumin messenger ribonucleic acid activity. Localization in polysomes, induction by estrogen, and effect of actinomycin D.卵清蛋白信使核糖核酸活性的定量测定。在多核糖体中的定位、雌激素诱导作用及放线菌素D的影响。
J Biol Chem. 1973 Mar 25;248(6):2031-9.
2
Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction.鸡输卵管中蛋白质合成的调控。I. 卵清蛋白、伴清蛋白、卵类黏蛋白和溶菌酶诱导的独立调控。
J Biol Chem. 1972 Oct 25;247(20):6450-61.
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Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawal of estrogen.
真核基因进化的机制。
Breast Cancer Res Treat. 1981;1(4):327-37. doi: 10.1007/BF01806748.
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[Gene structure and gene expression. Chicken lysozyme gene].[基因结构与基因表达。鸡溶菌酶基因]
Naturwissenschaften. 1981 Apr;68(4):170-6. doi: 10.1007/BF01047196.
5
Exons encode functional and structural units of chicken lysozyme.外显子编码鸡溶菌酶的功能和结构单元。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5759-63. doi: 10.1073/pnas.77.10.5759.
6
The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA.TGGCA结合蛋白：一种识别双链线性DNA上对称序列的真核细胞核蛋白。
Nucleic Acids Res. 1984 May 25;12(10):4295-311. doi: 10.1093/nar/12.10.4295.
7
Isolation and characterization of the rat tryptophan oxygenase gene.大鼠色氨酸加氧酶基因的分离与鉴定
EMBO J. 1982;1(10):1287-93. doi: 10.1002/j.1460-2075.1982.tb00026.x.
8
Transient expression of the chicken lysozyme gene after transfer into human cells.鸡溶菌酶基因转入人细胞后的瞬时表达。
EMBO J. 1982;1(10):1207-12. doi: 10.1002/j.1460-2075.1982.tb00014.x.
9
Nuclease-hypersensitive sites in the chromatin domain of the chicken lysozyme gene.鸡溶菌酶基因染色质结构域中的核酸酶超敏位点。
Nucleic Acids Res. 1983 Jun 11;11(11):3467-85. doi: 10.1093/nar/11.11.3467.
10
Gene shuttling: moving of cloned DNA into and out of eukaryotic cells.基因穿梭：将克隆的DNA导入真核细胞并从真核细胞中导出。
Nucleic Acids Res. 1982 Feb 25;10(4):1243-56. doi: 10.1093/nar/10.4.1243.
雌激素急性撤除后卵清蛋白信使核糖核酸的快速失活
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2357-61. doi: 10.1073/pnas.71.6.2357.
4
Synergistic effects of oesterogen and progesterone on ovomucoid and conalbumin mRNA synthesis in chick oviduct.雌激素与孕酮对雏鸡输卵管中卵类粘蛋白和伴清蛋白mRNA合成的协同作用。
Nat New Biol. 1973 Nov 21;246(151):74-6. doi: 10.1038/newbio246074a0.
5
Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones.类固醇激素诱导卵清蛋白和抗生物素蛋白特异性可翻译信使核糖核酸的速率。
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1870-4. doi: 10.1073/pnas.70.6.1870.
6
Quantitation of ovalbumin mRNA in hen and chick oviduct by hybridization to complementary DNA. Accumulation of specific mRNA in response to estradiol.通过与互补DNA杂交对母鸡和雏鸡输卵管中卵清蛋白信使核糖核酸进行定量分析。特定信使核糖核酸在雌二醇作用下的积累。
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Induction of ovalbumin mRNA sequences by estrogen and progesterone in chick oviduct as measured by hybridization to complementary DNA.通过与互补DNA杂交测定雌激素和孕酮对鸡输卵管中卵清蛋白mRNA序列的诱导作用。
J Biol Chem. 1975 Oct 25;250(20):8105-10.
9
Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli.用于由流感嗜血杆菌的限制性内切核酸酶III和大肠杆菌的限制性内切核酸酶I制备的DNA片段的噬菌体λ受体染色体。
J Mol Biol. 1975 Nov 5;98(3):551-64. doi: 10.1016/s0022-2836(75)80086-6.
10
The structure of histone-depleted metaphase chromosomes.组蛋白缺失的中期染色体结构。
Cell. 1977 Nov;12(3):817-28. doi: 10.1016/0092-8674(77)90280-x.