血管舒张药物对原发性高血压患者颈总动脉和肱动脉循环的血流动力学影响。
Haemodynamic effects of vasodilating drugs on the common carotid and brachial circulations of patients with essential hypertension.
作者信息
Bouthier J D, Safar M E, Benetos A, Simon A C, Levenson J A, Hugues C M
出版信息
Br J Clin Pharmacol. 1986 Feb;21(2):137-42. doi: 10.1111/j.1365-2125.1986.tb05167.x.
Abstract
The haemodynamic pattern of the common carotid artery was studied in men with sustained essential hypertension using pulsed Doppler methods before and after administration of vasodilating drugs. Captopril produced both a fall in vascular resistance and an increase in arterial diameter of the common carotid artery. Isosorbide dinitrate increased markedly the arterial diameter but did not change vascular resistance. Nitrendipine decreased vascular resistance with no change in the arterial diameter. In the common carotid circulation of patients with essential hypertension, vasodilating drugs may either dilate small arteries (nitrendipine), large arteries (isosorbide dinitrate), or both (captopril).
摘要
采用脉冲多普勒方法，在服用血管舒张药物前后，对患有持续性原发性高血压的男性患者的颈总动脉血流动力学模式进行了研究。卡托普利可降低血管阻力，并增加颈总动脉的动脉直径。硝酸异山梨酯可显著增加动脉直径，但不改变血管阻力。尼群地平可降低血管阻力，而动脉直径无变化。在原发性高血压患者的颈总动脉循环中，血管舒张药物可能会扩张小动脉（尼群地平）、大动脉（硝酸异山梨酯）或两者皆有（卡托普利）。
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本文引用的文献
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