Sakai Ryosuke, Hashimoto Yoshitaka, Ushigome Emi, Miki Akane, Okamura Takuro, Matsugasumi Masako, Fukuda Takuya, Majima Saori, Matsumoto Shinobu, Senmaru Takafumi, Hamaguchi Masahide, Tanaka Muhei, Asano Mai, Yamazaki Masahiro, Oda Yohei, Fukui Michiaki
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Department of Diabetology, Kameoka Municipal Hospital, Kyoto, Japan.
Endocr J. 2018 Apr 26;65(4):395-402. doi: 10.1507/endocrj.EJ17-0414. Epub 2018 Jan 27.
Skipping breakfast or irregular breakfast is associated with poor glycemic control. However, a relationship between the timing of dinner and glycemic control in people with type 2 diabetes remains indefinite. Therefore, we investigated the relationship between late-night-dinner and glycemic control in people with type 2 diabetes. We performed questionnaire survey for lifestyle factors in this cross-sectional study. We defined having dinner later than eight pm as late-night-dinner. We examined the differences in clinical and metabolic parameters between those who have late-night-dinner and those who do not have. We also examined the relationship between late-night-dinner and HbA1c, using multiple regression analysis. Ninety-five people (23.2%) had a late-night-dinner, among 409 people with type 2 diabetes. Metabolic parameters (mean (SD) or median (interquartile range)) of people with late-night-dinner were worse than those of without, including body mass index (BMI) (24.4 (4.0) vs. 23.2 (3.4) kg/m, p = 0.006), triglycerides (1.5 (1.1-2.1) vs. 1.2 (0.8-1.7) mmol/L, p < 0.001), HDL-cholesterol (1.4 (0.4) vs. 1.6 (0.4) mmol/L, p = 0.004) and hemoglobin A1c (58.1 (13.3) vs. 55.2 (10.2) mmol/mol, (7.5 (1.2) vs. 7.2 (0.9) %), p = 0.023)). Late-night-dinner (standardized regression coefficient = 0.13, p = 0.028) was associated with hemoglobin A1c after adjusting for age, BMI, sex, duration of diabetes, smoking, exercise, alcohol, snacking after dinner, nighttime sleep duration, time from dinner to bedtime, skipping breakfast, and medication for diabetes. Late-night-dinner is independently associated with poor glycemic control in people with type 2 diabetes.
不吃早餐或早餐不规律与血糖控制不佳有关。然而,2型糖尿病患者晚餐时间与血糖控制之间的关系仍不明确。因此,我们研究了2型糖尿病患者晚餐过晚与血糖控制之间的关系。在这项横断面研究中,我们对生活方式因素进行了问卷调查。我们将晚上8点后吃晚餐定义为晚餐过晚。我们研究了晚餐过晚者和未晚餐过晚者在临床和代谢参数上的差异。我们还使用多元回归分析研究了晚餐过晚与糖化血红蛋白(HbA1c)之间的关系。在409名2型糖尿病患者中,95人(23.2%)晚餐过晚。晚餐过晚者的代谢参数(均值(标准差)或中位数(四分位间距))比未晚餐过晚者更差,包括体重指数(BMI)(24.4(4.0)vs.23.2(3.4)kg/m²,p = 0.006)、甘油三酯(1.5(1.1 - 2.1)vs.1.2(0.8 - 1.7)mmol/L,p < 0.001)、高密度脂蛋白胆固醇(1.4(0.4)vs.1.6(0.4)mmol/L,p = 0.004)和糖化血红蛋白(58.1(13.3)vs.55.2(10.2)mmol/mol,(7.5(1.2)vs.7.2(0.9)%,p = 0.023))。在调整年龄、BMI、性别、糖尿病病程、吸烟、运动、饮酒、晚餐后吃零食、夜间睡眠时间、晚餐至就寝时间、不吃早餐和糖尿病用药情况后,晚餐过晚(标准化回归系数 = 0.13,p = 0.028)与糖化血红蛋白相关。晚餐过晚与2型糖尿病患者血糖控制不佳独立相关。