Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Centre Munich, German Centre for Lung Research. (DZL), University Hospital Munich of Ludwig Maximillians University Munich, Munich, Germany.
Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Curr Environ Health Rep. 2018 Mar;5(1):70-76. doi: 10.1007/s40572-018-0178-z.
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing worldwide with no known cure and an increasing number of triggers that exacerbate symptoms and speed up progression. This review aims to summarize the evidence for COPD patients being more vulnerable to air pollution exposure assessed as acute effects.
Several recent systematic reviews show consistently increased risks for COPD mortality and COPD hospital admission, ranging between 2 and 3% with increasing PM or PM. Similar adverse impacts were shown for NO Also adverse health effects among COPD patients were also found for other gaseous pollutants such as ozone and SO; most of these studies could not be included in the meta-analysis we reviewed. Data from ten panel studies of COPD patients reported a small but statistically significant decline of FEV1 [- 3.38 mL (95% CI - 6.39 to - 0.37)] per increment of 10 μg/m PM, supporting an impact on respiratory health with increasing PM exposure. The combined information from systematic reviews and more recent findings lead us to conclude that COPD patients are more vulnerable to ambient air pollution than healthier people.
慢性阻塞性肺疾病（COPD）在全球范围内的患病率不断上升，目前尚无已知的治愈方法，且能加重症状并加速疾病进展的诱因也越来越多。本综述旨在总结 COPD 患者对空气污染暴露更易产生急性影响的证据。
几项最近的系统评价一致表明，COPD 死亡率和 COPD 住院率的风险增加，范围在 2%至 3%之间，随着 PM 或 PM 的增加而增加。NO 也有类似的不良影响。臭氧和 SO 等其他气态污染物也对 COPD 患者的健康产生不良影响；我们综述中纳入的大多数研究无法纳入荟萃分析。对 COPD 患者进行的 10 项面板研究的数据报告称，每增加 10μg/m³ PM，FEV1 下降 -3.38mL（95%CI -6.39 至 -0.37），这支持了随着 PM 暴露增加对呼吸健康的影响。系统评价和最近发现的综合信息使我们得出结论，与健康人群相比，COPD 患者更容易受到环境空气污染的影响。
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