Almela Ramón M, Rubio Camila P, Cerón José J, Ansón Agustina, Tichy Alexander, Mayer Ursula
Kleintierspezialisten Augsburg Überweisungszentrum, Max-Josef-Metzger Straße 9, 86157, Augsburg, Germany.
Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100, Espinardo, Murcia, Spain.
Vet Dermatol. 2018 Jun;29(3):229-e82. doi: 10.1111/vde.12525. Epub 2018 Feb 1.
Oxidative stress (OS) has been shown to be involved in the pathogenesis of human and canine atopic dermatitis (AD) through several distinct mechanisms. Selected serum biomarkers of OS (sbOS) have been validated in normal dogs and studied in several canine diseases. To the best of the authors' knowledge, the sbOS evaluated in this study have not previously been described in canine AD.
HYPOTHESIS/OBJECTIVES: The aims of the study were to evaluate a panel of sbOS in dogs with food-induced (FIAD) and non-food-induced (NFIAD) AD: cupric reducing antioxidant capacity (CUPRAC), ferrous oxidation-xylenol orange (FOX), ferric reducing ability of the plasma (FRAP), paraoxonase-1 (PON1), trolox equivalent antioxidant capacity (TEAC) and serum total thiol (THIOL). The aim was to compare these metabolites with those in healthy control dogs, and to correlate sbOS with validated pruritus and CADESI-04 severity scales in dogs with AD.
Forty six healthy, nine NFIAD and three FIAD client-owned dogs were included.
The study was designed as a cohort study.
There were significant differences in atopic dogs when compared to healthy dogs for all of the sbOS analysed.
These findings suggest that OS could play a role in the pathogenesis of canine NFIAD and FIAD. In addition, the evaluation of sbOS could be useful for precision medicine to help to detect atopic dogs that might benefit from antioxidant-targeted therapies.
氧化应激（OS）已被证明通过多种不同机制参与人类和犬类特应性皮炎（AD）的发病过程。选定的氧化应激血清生物标志物（sbOS）已在正常犬中得到验证，并在多种犬类疾病中进行了研究。据作者所知，本研究中评估的sbOS此前尚未在犬类AD中描述过。
假设/目的：本研究的目的是评估一组食物诱导型（FIAD）和非食物诱导型（NFIAD）AD犬的sbOS：铜还原抗氧化能力（CUPRAC）、亚铁氧化二甲苯酚橙（FOX）、血浆铁还原能力（FRAP）、对氧磷酶-1（PON1）、特洛克斯等效抗氧化能力（TEAC）和血清总硫醇（THIOL）。目的是将这些代谢物与健康对照犬的代谢物进行比较，并将sbOS与AD犬经过验证的瘙痒和CADESI-04严重程度量表进行关联。
纳入了46只健康的、9只NFIAD和3只FIAD的客户拥有的犬。
本研究设计为队列研究。
与健康犬相比，所有分析的sbOS在特应性犬中均存在显著差异。
这些发现表明OS可能在犬类NFIAD和FIAD的发病机制中起作用。此外，sbOS的评估可能有助于精准医学，以帮助检测可能从抗氧化剂靶向治疗中受益的特应性犬。
