State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Division of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA.
J Cell Mol Med. 2018 Apr;22(4):2510-2513. doi: 10.1111/jcmm.13516. Epub 2018 Feb 1.
Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive-mechanical-loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule-fibromodulin (FMOD) protein-can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive-mechanical-loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and because red Duroc pigs show scarring that closely resembles human proliferative scarring and hypertrophic scarring, FMOD-based technologies hold high translational potential and applicability to human patients suffering from scarring-especially hypertrophic scarring.
增生性瘢痕是一种主要的术后并发症，会导致患者严重毁容和功能障碍，由于其高复发率，通常需要多次手术修复。过度机械负荷是增生性瘢痕形成的一个重要启动因素。在这项研究中，我们证明了真皮内单次给予细胞外基质（ECM）分子-纤维调节素（FMOD）蛋白可以显著减少瘢痕大小，增加拉伸强度，并改善正常甚至过度机械负荷的红色杜洛克猪创面模型中的真皮胶原结构组织。由于猪皮被美国食品和药物管理局（FDA）认定为与人类皮肤最接近的动物等效物，并且红色杜洛克猪的瘢痕形成与人类增生性瘢痕和肥厚性瘢痕非常相似，因此基于 FMOD 的技术具有很高的转化潜力和适用于患有瘢痕，尤其是肥厚性瘢痕的人类患者。
