利用亚硝基笼蔽罗丹明对溶酶体进行超分辨率成像。
Super-resolution imaging of lysosomes with a nitroso-caged rhodamine.
作者信息
He Haihong, Ye Zhiwei, Zheng Ying, Xu Xiu, Guo Chunlei, Xiao Yi, Yang Wei, Qian Xuhong, Yang Youjun
机构信息
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
出版信息
Chem Commun (Camb). 2018 Mar 15;54(23):2842-2845. doi: 10.1039/c7cc08886h.
Caged-fluorophores are potentially suitable for photo-activated localization microscopy (PALM) for super-resolution imaging. N-Nitroso is a simple and robust photo-cage with biocompatible nitric oxide as the only byproduct upon photolysis. We herein reported a novel PALM probe (NOR535) for super-resolution imaging of lysosomes with high localization precision.
笼状荧光团可能适用于用于超分辨率成像的光激活定位显微镜（PALM）。N-亚硝基是一种简单且稳定的光笼，光解时唯一的副产物是具有生物相容性的一氧化氮。我们在此报告了一种新型的用于溶酶体超分辨率成像的PALM探针（NOR535），其具有高定位精度。
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