The Yale Stress Center, Yale University School of Medicine, Department of Psychiatry, 2 Church Street South, Suite 209, New Haven, CT 06519, USA.
The Yale Stress Center, Yale University School of Medicine, Department of Psychiatry, 2 Church Street South, Suite 209, New Haven, CT 06519, USA.
Trends Mol Med. 2018 Feb;24(2):173-186. doi: 10.1016/j.molmed.2017.12.010. Epub 2018 Jan 25.
Substance use disorders (SUDs) are marked by heterogeneity in clinical symptomatology and high relapse rates following treatment. Here, we describe specific peripheral and central stress responses associated with the pathophysiology of SUDs. We outline potential stress response measures, including hypothalamus-pituitary-adrenal axis markers, autonomic responses, and central structural and functional brain alterations that could be exploited as putative biomarkers in SUDs. We posit that stress responses can be predictive of both the development of SUDs and their high relapsing nature. We examine their potential as candidate biomarkers, as well as the remaining challenges in developing and implementing their application for the prevention and treatment of SUDs.
物质使用障碍（SUDs）的临床症状表现具有异质性，且治疗后复发率很高。在这里，我们描述了与 SUD 病理生理学相关的特定外周和中枢应激反应。我们概述了潜在的应激反应措施，包括下丘脑-垂体-肾上腺轴标志物、自主反应以及中枢结构和功能脑改变，这些都可以作为 SUD 的潜在生物标志物。我们认为应激反应可以预测 SUD 的发展及其高复发性质。我们研究了它们作为候选生物标志物的潜力，以及在开发和实施其用于预防和治疗 SUD 方面仍然存在的挑战。
