Bruze M, Dahlquist I, Fregert S, Gruvberger B, Persson K
Contact Dermatitis. 1987 Apr;16(4):183-8. doi: 10.1111/j.1600-0536.1987.tb01421.x.
The preservative Kathon CG is a commercial preparation, consisting of 2 active ingredients and other components. 28 patients with contact allergy to Kathon CG participated in a study in which patch testing was performed with serial dilutions, and with 5 chromatographically separated fractions. All reacted to fraction IV, and 2 patients also to fraction II. Mass spectrometry and nuclear magnetic resonance spectrometry identified fraction II and IV to be the active ingredients; 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one.
防腐剂凯松CG是一种商业制剂，由2种活性成分和其他成分组成。28名对凯松CG有接触性过敏的患者参与了一项研究，该研究中进行了系列稀释以及5种色谱分离组分的斑贴试验。所有人对组分IV有反应，2名患者对组分II也有反应。质谱分析和核磁共振光谱分析确定组分II和IV为活性成分，即2-甲基-4-异噻唑啉-3-酮和5-氯-2-甲基-4-异噻唑啉-3-酮。
