Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Dev Cell. 2018 Jan 22;44(2):133-135. doi: 10.1016/j.devcel.2018.01.001.
Selective autophagy of the endoplasmic reticulum (ER)-ER-phagy-is mediated by multiple receptors. In this issue of Developmental Cell, Smith et al. (2018) identify ER membrane protein CCPG1 as an ER-phagy receptor that interacts with autophagy-related proteins GABARAPs and FIP200 and ensures ER protein homeostasis, especially in pancreatic acinar cells.
选择性自噬内质网（ER）-ER 自噬是由多种受体介导的。在本期《发育细胞》中，Smith 等人（2018 年）鉴定出 ER 膜蛋白 CCPG1 是一种 ER 自噬受体，它与自噬相关蛋白 GABARAPs 和 FIP200 相互作用，确保 ER 蛋白的动态平衡，尤其是在胰腺腺泡细胞中。
