Zhang Zeng-Wang, Chen Jia-Jun, Xia Shi-Hui, Zhao Hua, Yang Jun-Bo, Zhang Hao, He Bin, Jiao Jun, Zhan Bo-Tao, Sun Cheng-Cao
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.
Gene. 2018 Apr 15;650:60-67. doi: 10.1016/j.gene.2018.01.096. Epub 2018 Jan 31.
Growing evidence shows that long non-coding RNAs (lncRNAs) have been wildly verified to modulate multiple tumorigenesis, especially lung adenocarcinoma. In present study, we aim to investigate the role of lncRNA LINC00319 in the lung adenocarcinoma carcinogenesis. We observed that increased expression of LINC00319 in lung adenocarcinoma tissues and cells in comparison to their corresponding controls. Moreover, the aberrant overexpression of LINC00319 indicated the poor prognosis of lung adenocarcinoma patients. Silence of LINC00319 was able to repress lung adenocarcinoma cell growth in vitro. Rescue assay was performed to further confirm that LINC00319 contributed to lung adenocarcinoma progression by regulating miR-450b-5p/EZH2 signal pathway. Taken together, our study discovered the oncogenic role of LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR-450b-5p/EZH2 pathway. This results and findings provide a novel insight for lung adenocarcinoma tumorigenesis.
越来越多的证据表明，长链非编码RNA（lncRNAs）已被广泛证实可调节多种肿瘤的发生，尤其是肺腺癌。在本研究中，我们旨在探讨lncRNA LINC00319在肺腺癌发生中的作用。我们观察到，与相应对照相比，LINC00319在肺腺癌组织和细胞中的表达增加。此外，LINC00319的异常过表达表明肺腺癌患者预后不良。沉默LINC00319能够在体外抑制肺腺癌细胞的生长。进行了挽救实验以进一步证实LINC00319通过调节miR-450b-5p/EZH2信号通路促进肺腺癌进展。综上所述，我们的研究在临床标本和细胞实验中发现了LINC00319的致癌作用，揭示了潜在的LINC00319/miR-450b-5p/EZH2通路。这些结果和发现为肺腺癌的肿瘤发生提供了新的见解。
