Disease Elimination Program, Life Sciences Discipline, Burnet Institute, 85 Commercial Rd, Melbourne, Victoria, 3004, Australia.
Department of Microbiology, Monash University, Clayton, VIC, 3168, Australia.
Microbiome. 2018 Feb 6;6(1):29. doi: 10.1186/s40168-018-0418-3.
In the cervicovaginal environment, the production of hydrogen peroxide (HO) by vaginal Lactobacillus spp. is often mentioned as a critical factor to the in vivo vaginal microbiota antimicrobial properties. We present several lines of evidence that support the implausibility of HO as an "in vivo" contributor to the cervicovaginal milieu antimicrobial properties. An alternative explanation is proposed, supported by previous reports ascribing protective and antimicrobial properties to other factors produced by Lactobacillus spp. capable of generating HO. Under this proposal, lactic acid rather than HO plays an important role in the antimicrobial properties of protective vaginal Lactobacillus spp. We hope this commentary will help future research focus on more plausible mechanisms by which vaginal Lactobacillus spp. exert their antimicrobial and beneficial properties, and which have in vivo and translational relevance.
在宫颈阴道环境中，阴道乳杆菌属产生过氧化氢（HO）通常被认为是阴道微生物组抗菌特性的一个关键因素。我们提出了一些证据，这些证据表明 HO 不太可能作为“体内”对宫颈阴道环境抗菌特性的贡献者。提出了一种替代解释，该解释得到了先前报告的支持，这些报告将保护和抗菌特性归因于乳杆菌属产生 HO 的其他因素。根据这一建议，乳酸而不是 HO 在保护性阴道乳杆菌属的抗菌特性中发挥重要作用。我们希望本评论将有助于未来的研究将重点放在更合理的机制上，这些机制使阴道乳杆菌属发挥其抗菌和有益特性，并且具有体内和转化相关性。
