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基于机器学习方法的癫痫发作预测

Epileptic Seizures Prediction Using Machine Learning Methods.

作者信息

Usman Syed Muhammad, Usman Muhammad, Fong Simon

机构信息

Shaheed Zulfikar Ali Bhutto Institute of Science and Technology, Islamabad, Pakistan.

University of Macau, Macau.

出版信息

Comput Math Methods Med. 2017;2017:9074759. doi: 10.1155/2017/9074759. Epub 2017 Dec 19.

Abstract

Epileptic seizures occur due to disorder in brain functionality which can affect patient's health. Prediction of epileptic seizures before the beginning of the onset is quite useful for preventing the seizure by medication. Machine learning techniques and computational methods are used for predicting epileptic seizures from Electroencephalograms (EEG) signals. However, preprocessing of EEG signals for noise removal and features extraction are two major issues that have an adverse effect on both anticipation time and true positive prediction rate. Therefore, we propose a model that provides reliable methods of both preprocessing and feature extraction. Our model predicts epileptic seizures' sufficient time before the onset of seizure starts and provides a better true positive rate. We have applied empirical mode decomposition (EMD) for preprocessing and have extracted time and frequency domain features for training a prediction model. The proposed model detects the start of the preictal state, which is the state that starts few minutes before the onset of the seizure, with a higher true positive rate compared to traditional methods, 92.23%, and maximum anticipation time of 33 minutes and average prediction time of 23.6 minutes on scalp EEG CHB-MIT dataset of 22 subjects.

摘要

癫痫发作是由于大脑功能紊乱引起的,这会影响患者的健康。在癫痫发作开始前进行预测对于通过药物预防发作非常有用。机器学习技术和计算方法被用于从脑电图(EEG)信号中预测癫痫发作。然而,对EEG信号进行去噪和特征提取的预处理是两个主要问题,它们对预测时间和真阳性预测率都有不利影响。因此,我们提出了一个模型,该模型提供了可靠的预处理和特征提取方法。我们的模型在癫痫发作开始前有足够的时间进行预测,并提供了更好的真阳性率。我们应用经验模态分解(EMD)进行预处理,并提取了时域和频域特征来训练预测模型。与传统方法相比,该模型检测发作前状态(即发作开始前几分钟开始的状态)的真阳性率更高,在22名受试者的头皮EEG CHB-MIT数据集上,真阳性率为92.23%,最大预测时间为33分钟,平均预测时间为23.6分钟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d077/5749318/8b48468d8c2f/CMMM2017-9074759.001.jpg

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