Institute for Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
Centre for Infection Medicine, Institute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany.
Environ Microbiol Rep. 2018 Apr;10(2):140-154. doi: 10.1111/1758-2229.12628. Epub 2018 Feb 23.
Only relatively recently has research on the metabolism of intracellular bacterial pathogens within their host cells begun to appear in the published literature. This reflects in part the experimental difficulties encountered in separating host metabolic processes from those of the resident pathogen. One of the most genetically tractable and thoroughly studied intracellular bacterial pathogens, Salmonella enterica serovar Typhimurium (S. Typhimurium), has been at the forefront of metabolic studies within eukaryotic host cells. In this review, we offer a synthesis of what has been discovered to date regarding the metabolic adaptation of S. Typhimurium to survival and growth within the infected host. We discuss many studies in the context of techniques used, types of host cells, how host metabolites contribute to intracellular survival and proliferation of the pathogen and how bacterial metabolism affects the virulence and persistence of the pathogen.
直到最近，有关细胞内细菌病原体在宿主细胞内代谢的研究才开始出现在已发表的文献中。这在一定程度上反映了在分离宿主代谢过程与驻留病原体代谢过程方面所遇到的实验困难。鼠伤寒沙门氏菌（Salmonella enterica serovar Typhimurium，S. Typhimurium）是一种遗传上最易处理且研究最透彻的细胞内细菌病原体，它一直处于真核宿主细胞内代谢研究的前沿。在这篇综述中，我们综合了迄今为止有关 S. Typhimurium 在受感染宿主中存活和生长的代谢适应的发现。我们根据所使用的技术、宿主细胞类型、宿主代谢物如何有助于病原体的细胞内存活和增殖以及细菌代谢如何影响病原体的毒力和持久性等方面来讨论许多研究。
