Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Physiology, School of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Pharmacol Res. 2018 Mar;129:44-55. doi: 10.1016/j.phrs.2018.01.012. Epub 2018 Feb 3.
Irisin is a hormone-like molecule mainly released by skeletal muscles in response to exercise. Irisin induces browning of the white adipose tissue and has been shown to regulate glucose and lipid homeostasis. Keeping its energy expenditure and metabolic properties in view, numerous studies have focused on its therapeutic potential for the treatment of metabolic disorders like obesity and type 2 diabetes. Recently, the anti-inflammatory, anti-apoptotic and anti-oxidative properties of irisin have received a great deal of attention of the scientific society. These pathogenic processes are often associated with initiation, progression, and prognosis of numerous diseases like myocardial infarction, kidney diseases, cancer, lung injury, inflammatory bowel diseases, atherosclerosis, liver diseases, obesity and type 2 diabetes. In the current review, we present evidence regarding the anti-inflammatory, anti-apoptotic and anti-oxidative potential of irisin pertaining to various pathological conditions. Here, we explore multiple molecular pathways targeted by irisin therapy. Given the promising effects of irisin, many diseases with evident oxidative stress, inflammation and apoptosis can be targeted by irisin.
鸢尾素是一种激素样分子，主要由骨骼肌在运动时释放。鸢尾素可诱导白色脂肪组织的棕色化，并已被证明可调节葡萄糖和脂质的稳态。鉴于其能量消耗和代谢特性，许多研究都集中在其治疗肥胖症和 2 型糖尿病等代谢紊乱的潜在治疗作用上。最近，鸢尾素的抗炎、抗凋亡和抗氧化特性受到科学界的广泛关注。这些致病过程通常与多种疾病的发生、进展和预后有关，如心肌梗死、肾脏疾病、癌症、肺损伤、炎症性肠病、动脉粥样硬化、肝脏疾病、肥胖症和 2 型糖尿病。在目前的综述中，我们提供了与各种病理状况相关的鸢尾素抗炎、抗凋亡和抗氧化潜力的证据。在这里，我们探讨了鸢尾素治疗作用所针对的多种分子途径。鉴于鸢尾素的良好效果，许多具有明显氧化应激、炎症和细胞凋亡的疾病都可以通过鸢尾素来治疗。
