癌症蛋白质组全景与人类蛋白质组组织癌症蛋白质组计划
The cancer proteomic landscape and the HUPO Cancer Proteome Project.
作者信息
Jimenez Connie R, Zhang Hui, Kinsinger Christopher R, Nice Edouard C
机构信息
1OncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
2Department of Pathology, Mass Spectrometry Core Facility, Center for Biomarker Discovery and Translation, Johns Hopkins University, Baltimore, MD 21287 USA.
出版信息
Clin Proteomics. 2018 Jan 25;15:4. doi: 10.1186/s12014-018-9180-6. eCollection 2018.
The Human Cancer Proteome Project (Cancer-HPP) is an international initiative organized by HUPO whose key objective is to decipher the human cancer proteome through a coordinated effort by cancer proteome researchers around the world. The ultimate goal is to map the entire human cancer proteome to disclose tumor biology and drive improved diagnostics, treatment and management of cancer. Here we report the progress in the cancer proteomics field to date, and discuss future proteomic developments that will be needed to optimally delineate cancer phenotypes and advance the molecular characterization of this significant disease that is one of the leading causes of death worldwide.
人类癌症蛋白质组计划（Cancer-HPP）是由人类蛋白质组组织（HUPO）发起的一项国际倡议，其主要目标是通过全球癌症蛋白质组研究人员的协同努力来解析人类癌症蛋白质组。最终目标是绘制出完整的人类癌症蛋白质组图谱，以揭示肿瘤生物学特性，并推动癌症诊断、治疗和管理水平的提高。在此，我们报告了迄今为止癌症蛋白质组学领域的进展，并讨论了未来蛋白质组学的发展方向，这些发展对于最佳地描绘癌症表型以及推进对这种作为全球主要死因之一的重大疾病的分子特征描述是必要的。
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