a Department of Infectious Diseases & Immunology , University of Florida , Gainesville , FL , USA.
b Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine , University of Florida , Gainesville , FL , USA.
Gut Microbes. 2018;9(3):279-287. doi: 10.1080/19490976.2017.1417731. Epub 2018 Feb 8.
Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes (L. m), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability of P. UF1 bacterium derived from the intestinal bacterial commensals of preterm infants fed human breast milk to significantly mitigate pathogen-induced inflammation limiting colonic tissue damage. Here we further elucidated the potential of P. UF1 to also regulate innate and T cells, particularly Th17 and Th1 cells, against systemic L. m infection. Data demonstrate that P. UF1 not only robustly regulated protective Th17 and Th1 cells, but also sustained regulatory T cells (Treg cells) resulting in accelerated L. m clearance. Together, regulation of pathogenic inflammation by a novel probiotic bacterium such as P. UF1 may illuminate a new strategy to specifically control Th17-Th1 cells via IL-10 Treg cells to limit systemic tissue damage induced by intracellular pathogens, including L. m.
调节 Th17 和 Th1 细胞对包括李斯特菌（Listeria monocytogenes，L. m）在内的胞内病原体的反应对于限制炎症引起的组织损伤至关重要。我们最近证明，源自母乳喂养的早产儿肠道共生菌的 UF1 菌能够显著减轻病原体引起的炎症，从而限制结肠组织损伤。在这里，我们进一步阐明了 UF1 菌调节先天免疫和 T 细胞，特别是 Th17 和 Th1 细胞，以对抗全身李斯特菌感染的潜力。数据表明，UF1 不仅强烈调节保护性 Th17 和 Th1 细胞，而且还维持调节性 T 细胞（Treg 细胞），从而加速李斯特菌清除。总之，新型益生菌细菌如 UF1 对致病性炎症的调节可能为通过 IL-10 Treg 细胞来特异性控制 Th17-Th1 细胞提供一种新策略，以限制包括李斯特菌在内的胞内病原体引起的全身组织损伤。
