Saha Debasis, Mukherjee Arnab
Chemistry Department, Indian Institute of Science Education and Research, Pune, 411008, India.
Biophys Rev. 2018 Jun;10(3):795-808. doi: 10.1007/s12551-018-0399-2. Epub 2018 Feb 8.
The remarkable progress in the field of ionic liquids (ILs) in the last two decades has involved investigations on different aspects of ILs in various conditions. The nontoxic and biocompatible nature of ILs makes them a suitable substance for the storage and application of biomolecules. In this regard, the aqueous IL solutions have attracted a large number of studies to comprehend the role of water in modulating various properties of biomolecules. Here, we review some of the recent studies on aqueous ILs that concern the role of water in altering the behavior of ILs in general and in case of biomolecules solvated in ILs. The different structural and dynamic effects caused by water have been highlighted. We discuss the different modes of IL interaction that are responsible for stabilization and destabilization of proteins and enzymes followed by examples of water effect on this. The role of water in the case of nucleic acid storage in ILs, an area which has mostly been underrated, also has been emphasized. Our discussions highlight the fact that the effects of water on IL behavior are not general and are highly dependent on the nature of the IL under consideration. Overall, we aim to draw attention to the significance of water dynamics in the aqueous IL solutions, a better understanding of which can help in developing superior storage materials for application purposes.
在过去二十年里，离子液体（ILs）领域取得了显著进展，涉及在各种条件下对离子液体不同方面的研究。离子液体的无毒和生物相容性使其成为生物分子储存和应用的合适物质。在这方面，离子液体水溶液吸引了大量研究，以了解水在调节生物分子各种性质中的作用。在此，我们综述了一些关于离子液体水溶液的最新研究，这些研究涉及水在一般情况下以及在离子液体中溶剂化的生物分子情况下改变离子液体行为的作用。突出了水引起的不同结构和动力学效应。我们讨论了导致蛋白质和酶稳定与不稳定的离子液体相互作用的不同模式，并举例说明了水对此的影响。水在离子液体中储存核酸方面的作用，这一领域大多被低估了，也得到了强调。我们的讨论突出了这样一个事实，即水对离子液体行为的影响并非普遍存在，且高度依赖于所考虑的离子液体的性质。总体而言，我们旨在提请人们注意离子液体水溶液中水动力学的重要性，更好地理解这一点有助于开发用于应用目的的优质储存材料。
