绑定还是不绑定：解开 G 蛋白偶联受体的多效性之谜。
To Bind or Not to Bind: Unravelling GPCR Polypharmacology.
机构信息
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia; School of Pharmacy, Fudan University, Shanghai 201203, China.
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia.
出版信息
Cell. 2018 Feb 8;172(4):636-638. doi: 10.1016/j.cell.2018.01.018.
Interaction of a single drug with multiple targets through "polypharmacology" is increasingly recognized as necessary for treatment of complex diseases, such as schizophrenia. G protein-coupled receptors (GPCRs) are major medicinal targets, and understanding the structural basis of both GPCR drug selectivity and promiscuity could provide novel avenues for drug development.
通过“多药理学”，一种药物与多个靶点相互作用，对于治疗精神分裂症等复杂疾病变得越来越重要。G 蛋白偶联受体（GPCR）是主要的药物靶点，了解 GPCR 药物选择性和混杂性的结构基础，可以为药物开发提供新途径。
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