Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2018 Apr;100:198-204. doi: 10.1016/j.biopha.2018.01.108. Epub 2018 Feb 16.
Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS.
强直性脊柱炎（AS）是一种炎症性自身免疫性疾病。AS 是脊柱关节病（SpA）的典型形式。AS 的确切病因尚未完全了解。但是炎症在疾病发病机制中起着关键作用。免疫系统由各种细胞、分泌介质和标志物来管理和调节免疫反应和炎症。任何扰乱这种调节和止血的因素都可能导致慢性炎症。在这篇综述中，我们讨论了几种先天和适应性免疫细胞在 AS 的触发、启动、发展和调节中的作用。
