听力障碍、轻度认知障碍与痴呆：队列研究的荟萃分析
Hearing Impairment, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Cohort Studies.
作者信息
Wei Jingkai, Hu Yirui, Zhang Li, Hao Qiang, Yang Ruowei, Lu Haidong, Zhang Xuan, Chandrasekar Eeshwar K
机构信息
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, Pennsylvania, USA.
出版信息
Dement Geriatr Cogn Dis Extra. 2017 Dec 21;7(3):440-452. doi: 10.1159/000485178. eCollection 2017 Sep-Dec.
BACKGROUND
To estimate a pooled association between hearing impairment and risk of mild cognitive impairment and dementia.
METHODS
PubMed, Embase, and Web of Science were searched for prospective cohort studies that examined the association between hearing impairment and risk of mild cognitive impairment and/or dementia. Random-effects models were fitted to estimate the summary risk ratios (RRs) and 95% confidence interval (CIs), which represents the pooled association between hearing impairment with risk of mild cognitive impairment and dementia, compared to subjects free of hearing impairment.
RESULTS
Four studies on hearing impairment with mild cognitive impairment and 7 studies on hearing impairment with dementia were included in the meta-analysis. A total of 15,521 subjects were studied with follow-up periods between 2 and 16.8 years. Hearing impairment was associated with a greater risk of mild cognitive impairment (RR = 1.30, 95% CI: 1.12, 1.51) and dementia (RR = 2.39, 95% CI: 1.58, 3.61).
CONCLUSIONS
The meta-analysis showed that hearing impairment is associated with a higher risk of mild cognitive impairment and dementia among older adults.
背景
评估听力障碍与轻度认知障碍及痴呆风险之间的合并关联。
方法
检索PubMed、Embase和Web of Science数据库，查找检验听力障碍与轻度认知障碍和/或痴呆风险之间关联的前瞻性队列研究。采用随机效应模型来估计汇总风险比（RRs）和95%置信区间（CIs），该区间代表了与无听力障碍的受试者相比，听力障碍与轻度认知障碍及痴呆风险之间的合并关联。
结果
荟萃分析纳入了4项关于听力障碍与轻度认知障碍的研究以及7项关于听力障碍与痴呆的研究。总共对15521名受试者进行了研究，随访期为2至16.8年。听力障碍与更高的轻度认知障碍风险（RR = 1.30，95% CI：1.12，1.51）和痴呆风险（RR = 2.39，95% CI：1.58，3.61）相关。
结论
荟萃分析表明，听力障碍与老年人中更高的轻度认知障碍和痴呆风险相关。
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