Eriksen Jane N, Prahm August P, Falk Mads Krüger, Arrigoni Eva, Jeppesen Palle B, Larsen Michael, Dragsted Lars O
Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark.
Agroscope, Competence Division Plants and Plant Products, Schloss 1, CH-8820 Wädenswil, Switzerland.
J Nutr Sci. 2018 Feb 5;7:e8. doi: 10.1017/jns.2017.71. eCollection 2018.
Reduced absorption capacity in patients with intestinal resections (IR) could result in malabsorption of fat-soluble components like carotenoids, which are of clinical interest in relation to visual health. In this case cohort, we investigated the association between IR and serum lutein, zeaxanthin, β-carotene and macular pigment optical density, when compared with healthy controls. Ten patients with IR and twelve healthy controls were included in the study. Baseline characteristics were comparable between groups, except for higher serum TAG ( < 0·05) and shorter bowel length ( < 0·0001) in the group with IR. Serum lutein, zeaxanthin, β-carotene and macular pigment optical density were >15 % lower in the patient group compared with healthy controls ( < 0·05, adjusted for age) and, in the case of serum lutein and zeaxanthin, also for dietary intake of carotenoids. Results suggest that for a test of macular carotenoid supplementation, subjects with a potentially clinically significant carotenoid deficit could be recruited among patients with IR.
肠道切除患者（IR）的吸收能力降低可能导致类胡萝卜素等脂溶性成分吸收不良，而类胡萝卜素与视觉健康相关，具有临床研究价值。在本病例队列研究中，我们将IR患者与健康对照进行比较，调查了IR与血清叶黄素、玉米黄质、β-胡萝卜素及黄斑色素光密度之间的关联。该研究纳入了10例IR患者和12例健康对照。除IR组血清甘油三酯水平较高（<0.05）和肠长度较短（<0.0001）外，两组间的基线特征具有可比性。与健康对照相比，患者组血清叶黄素、玉米黄质、β-胡萝卜素及黄斑色素光密度降低超过15%（经年龄校正后，P<0.05），血清叶黄素和玉米黄质的情况还与类胡萝卜素的膳食摄入量有关。结果表明，对于黄斑类胡萝卜素补充试验，可在IR患者中招募可能存在具有临床意义的类胡萝卜素缺乏的受试者。
