环状 RNA：癌症诊断和治疗的新前沿。
Circular RNAs: a new frontier for cancer diagnosis and therapy.
机构信息
Laboratory of Gastrointestinal Onco-Pathology, Cancer Institute & General Surgery Institute, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, Liaoning Province, 110001, China.
出版信息
J Hematol Oncol. 2018 Feb 13;11(1):21. doi: 10.1186/s13045-018-0569-5.
In recent years, circular RNAs (circRNAs) have attracted considerable attention because they play a significant role in many fields of cancer biology. Additionally, it has become increasingly clear that circRNAs have the potential to make contributions to the successful application of individualized cancer medicine. This brief review introduces circRNAs by describing their potential as a biomarker and therapeutic target and discussing the possible strategies to target them. This review also presents the challenges that are encountered by circRNAs for their definitive entry into clinical practice. Clearly, our understanding of circRNAs helps to add a new dimension to the molecular structure of cancer and will provide many new opportunities for cancer treatment.
近年来，环状 RNA（circRNAs）因其在癌症生物学的许多领域发挥着重要作用而引起了广泛关注。此外，越来越明显的是，circRNAs 有可能为个体化癌症医学的成功应用做出贡献。这篇简短的综述通过描述其作为生物标志物和治疗靶点的潜力，并讨论靶向它们的可能策略，介绍了 circRNAs。本文还介绍了 circRNAs 在进入临床实践时所面临的挑战。显然，我们对 circRNAs 的认识有助于为癌症的分子结构增添新的维度，并为癌症治疗提供许多新的机会。
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