Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
Elife. 2018 Feb 13;7:e34783. doi: 10.7554/eLife.34783.
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in -null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in -null mice. Young adult null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.
髓鞘是轴突的绝缘鞘，支持轴突的功能。一个重要的问题是轻度脱髓鞘的影响。在缺乏髓鞘蛋白少突胶质细胞髓鞘糖蛋白 (PLP1) 的情况下，髓鞘虽然会生成，但随着年龄的增长，轴突的功能/维持会受到干扰。-null 小鼠的皮质投射神经元早在 2 个月大时就出现了轴突中断。高容量细胞定量技术显示，嗅球和额皮质胼胝体的少突胶质细胞密度在成年期增加。在侧脑室下区 (SVZ) 观察到祖细胞的明显增殖反应，而室管膜下区的少突胶质前体细胞的数量和增殖没有变化。这种 SVZ 增殖反应发生在轴突中断之前。因此，SVZ 的这种新型反应有助于解释 -null 小鼠中少突胶质细胞的区域特异性增加。年轻成年的 null 小鼠表现出微妙但实质性的行为改变，表明轻度脱髓鞘对其有早期影响。
