圆锥角膜中国青少年的眼部尺寸
Ocular dimensions of the Chinese adolescents with keratoconus.
作者信息
Jian Weijun, Shen Yang, Chen Yingjun, Tian Mi, Zhou Xingtao
机构信息
The Eye and ENT Hospital of Fudan University, Shanghai, China.
The Key Lab of Myopia, Ministry of Health, People's Republic of China, 19 Baoqing Road, Shanghai, Xuhui District, China.
出版信息
BMC Ophthalmol. 2018 Feb 13;18(1):43. doi: 10.1186/s12886-018-0713-6.
BACKGROUND
Adolescent KC is a special segment of the general KC population because an adolescents's eyes are still susceptible to blurred vision and optical defocus during the sensitive period of ocular and visual development. In the present study, we evaluated the ocular dimensions of 53 KC adolescents.
METHODS
One hundred and six KC eyes of 53 (42 boys and 11 girls) KC adolescents (age 15.5 ± 1.7 years, range 11 to 18) were involved in this retrospective study. The eye with more severe KC (Severe Group) of each patient was compared with their less affected eye (Mild Group). Optical axial length (OAL) was measured by optical coherence biometry (IOL-master). Central corneal thickness, anterior chamber depth (ACD), flat keratometry value, steep keratometry value, and maximum keratometry value were assessed with an anterior segment analyzer (Pentacam HR). Anterior segment length (ASL) was manually measured from the 25 scheimpflug images captured by the Pentacam HR with the mean value recorded. The posterior segment length (PSL) was calculated with the formula "PSL = OAL-ASL".
RESULTS
The mean ACD, OAL, ASL, and PSL values of the Severe Group were 3.51 ± 0.32 mm, 24.76 ± 1.24 mm, 4.01 ± 0.30 mm and 20.76 ± 1.15 mm.While those of the Mild Group were 3.36 ± 0.29 mm, 24.97 ± 1.40 mm, 3.94 ± 0.35 mm and 21.03 ± 1.31 mm. The Severe Group has significantly higher ACD (t = 4.539, P < 0.001) value but lower OAL (t = - 3.120, P = 0.003) and PSL (t = - 4.537, P < 0.001) values when compared with those of the Mild Group. For the Severe Group, the Kmax values were significantly correlated with the SE values (R = - 0.385, P = 0.004), the ACD values (R = 0.375, P = 0.006), the ASL values (R = 0.308, P = 0.025) and the PSL values (R = - 0.317, P = 0.021), but not with the OAL values (R = - 0.220, P = 0.114). In the Mild Group, the Kmax values were negatively correlated with the SE (R = - 0.577, P < 0.001), OAL(R = - 0.533, P < 0.001), and PSL (R = - 0.523, P < 0.001) values, but not with ACD (R = - 0.110, P = 0.434) or ASL (R = - 0.182, P = 0.192) values.
CONCLUSIONS
For adolescent KC, the more keratoconic eyes may be characterized by deeper ACD but shorter OAL and PSL, when compared with the less affected ones.
背景
青少年圆锥角膜是圆锥角膜总体人群中的一个特殊部分，因为青少年的眼睛在眼和视觉发育的敏感期仍易受视力模糊和光学离焦的影响。在本研究中，我们评估了53名圆锥角膜青少年的眼部尺寸。
方法
本回顾性研究纳入了53名（42名男孩和11名女孩）圆锥角膜青少年（年龄15.5±1.7岁，范围11至18岁）的106只圆锥角膜眼。将每位患者圆锥角膜更严重的眼（重度组）与其受影响较小的眼（轻度组）进行比较。采用光学相干生物测量法（IOL-master）测量眼轴长度（OAL）。使用眼前节分析仪（Pentacam HR）评估中央角膜厚度、前房深度（ACD）、平坦角膜曲率值、陡峭角膜曲率值和最大角膜曲率值。从Pentacam HR采集的25张Scheimpflug图像中手动测量眼前节长度（ASL），记录平均值。后节长度（PSL）通过公式“PSL = OAL - ASL”计算得出。
结果
重度组的平均ACD、OAL、ASL和PSL值分别为3.51±0.32mm、24.76±1.24mm、4.01±0.30mm和20.76±1.15mm。而轻度组的分别为3.36±0.29mm、24.97±1.40mm、3.94±0.35mm和21.03±1.31mm。与轻度组相比，重度组的ACD值显著更高（t = 4.539，P < 0.001），但OAL（t = -3.120，P = 0.003）和PSL（t = -4.537，P < 0.001）值更低。对于重度组，Kmax值与SE值（R = -0.385，P = 0.004）、ACD值（R = 0.375，P = 0.006）、ASL值（R = 0.308，P = 0.025）和PSL值（R = -0.317，P = 0.021）显著相关，但与OAL值（R = -0.220，P = 0.114）无关。在轻度组中，Kmax值与SE（R = -0.577，P < 0.001）、OAL（R = -0.533，P < 0.001）和PSL（R = -0.523，P < 0.001）值呈负相关，但与ACD（R = -0.110，P = 0.434）或ASL（R = -0.182，P = 0.192）值无关。
结论
对于青少年圆锥角膜，与受影响较小的眼睛相比，圆锥角膜更严重的眼睛可能具有更深的ACD，但OAL和PSL更短。
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