Meyer Jay J, Gokul Akilesh, Vellara Hans R, Prime Zak, McGhee Charles N J
Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Am J Ophthalmol. 2017 Mar;175:122-128. doi: 10.1016/j.ajo.2016.12.003. Epub 2016 Dec 18.
To assess the repeatability and agreement of keratometry and pachymetry measurements obtained using 3 tomographers in eyes with keratoconus.
Reliability analysis.
setting: Institutional.
Fifty eyes of 50 participants with keratoconus. observational procedure: Steep keratometry, flat keratometry, central corneal thickness (CCT), and thinnest corneal thickness (TCT) measurements using Galilei, Orbscan II, and Pentacam HR.
Repeatability was assessed using within-subject standard deviation (S), coefficient of variation (CV), and intraclass correlation coefficient (ICC). Bland-Altman plots and 95% limits of agreement (LoA) were used to evaluate agreement between device pairs.
For all studied parameters, ICC was >0.97 with the least repeatable measurements obtained using Orbscan II. Mean steep keratometry values were similar while mean flat keratometry values were significantly different between all devices. The Galilei and Pentacam HR had the lowest 95% LoA for both CCT and TCT. There were no significant differences in mean CCT between Galilei and Pentacam HR. Mean Orbscan II CCT measurements were not significantly different overall but had wide 95% LoA with Pentacam HR (-47.95 to 58.09 μm) and Galilei (-43.70 to 53.91 μm). Mean Orbscan II CCT measurements were significantly lower when an acoustic factor of 0.92 was applied (-33.6 μm vs Pentacam HR, P < .001; -33.6 μm vs Galilei; P < .001).
Keratometric and pachymetric measurements of keratoconic eyes obtained by Galilei, Orbscan II, and Pentacam were disparate. Measurements were less repeatable with Orbscan II compared with Pentacam HR and Galilei, although overall repeatability was high for all instruments.
评估使用3种眼前节分析仪在圆锥角膜眼中获得的角膜曲率测量值和角膜厚度测量值的可重复性及一致性。
可靠性分析。
机构研究。
50例圆锥角膜患者的50只眼。观察程序：使用Galilei、Orbscan II和Pentacam HR测量陡峭角膜曲率、平坦角膜曲率、中央角膜厚度（CCT）和最薄角膜厚度（TCT）。
使用受试者内标准差（S）、变异系数（CV）和组内相关系数（ICC）评估可重复性。采用Bland-Altman图和95%一致性界限（LoA）评估仪器对之间的一致性。
对于所有研究参数，ICC均>0.97，其中使用Orbscan II获得的测量值可重复性最低。所有仪器之间，平均陡峭角膜曲率值相似，而平均平坦角膜曲率值存在显著差异。Galilei和Pentacam HR在CCT和TCT方面的95% LoA最低。Galilei和Pentacam HR之间的平均CCT无显著差异。Orbscan II的平均CCT测量值总体上无显著差异，但与Pentacam HR（-47.95至58.09μm）和Galilei（-43.70至53.91μm）的95% LoA较宽。当应用0.92的声学因子时，Orbscan II的平均CCT测量值显著降低（与Pentacam HR相比为-33.6μm，P <.001；与Galilei相比为-33.6μm，P <.001）。
Galilei、Orbscan II和Pentacam获得的圆锥角膜眼的角膜曲率和角膜厚度测量值存在差异。与Pentacam HR和Galilei相比，Orbscan II的测量值可重复性较低，尽管所有仪器的总体可重复性较高。
