Ullah Khan Shahid, Saleh Tawfik A, Wahab Abdul, Khan Muhammad Hafeez Ullah, Khan Dilfaraz, Ullah Khan Wasim, Rahim Abdur, Kamal Sajid, Ullah Khan Farman, Fahad Shah
College of Plant Sciences and Technology.
National Key Laboratory of Crop Genetics Improvement, Huazhong Agricultural University, Wuhan, People's Republic of China.
Int J Nanomedicine. 2018 Feb 2;13:733-762. doi: 10.2147/IJN.S153167. eCollection 2018.
Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the versatile application of AgNPs in cosmetics, electronics, and medical fields.
近年来，银纳米技术因其在各个领域的广泛应用及其固有的治疗特性而受到了极大关注。在本综述中，我们试图批判性地评估银纳米颗粒（AgNPs）的化学、物理和生物合成方法，以及它们在包括微生物学和寄生虫学在内的治疗诊断领域的功效。此外，还展望了AgNPs在对抗不同生物系统（如细菌、真菌、病毒和寄生虫（利什曼原虫和疟原虫））以治愈某些致命人类疾病方面的表现，特别关注了癌症。AgNPs在不同生物系统中的作用机制仍然不明。在此，由于现有文献有限，我们仅关注AgNPs在包括人类（伤口愈合和细胞凋亡）、细菌和病毒等生物系统中的作用机制，这可能为未来研究打开新的窗口，以确保AgNPs在化妆品、电子和医学领域的广泛应用。
