Biologics Division, Biopharmaceuticals and Herbal Medicine Evaluation Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, Korea.
Department of Applied Statistics, Yonsei University, Seoul, Korea.
J Korean Med Sci. 2018 Feb 19;33(8):e60. doi: 10.3346/jkms.2018.33.e60.
The goal of this study was to analyze the relationship between exercise frequency and all-cause mortality for individuals diagnosed with and without diabetes mellitus (DM).
We analyzed data for 505,677 participants (53.9% men) in the National Health Insurance Service-National Health Screening (NHIS-HEALS) cohort. The study endpoint variable was all-cause mortality.
Frequency of exercise and covariates including age, sex, smoking status, household income, blood pressure, fasting glucose, body mass index, total cholesterol, and Charlson comorbidity index were determined at baseline. Cox proportional hazard regression models were developed to assess the effects of exercise frequency (0, 1-2, 3-4, 5-6, and 7 days per week) on mortality, separately in individuals with and without DM. We found a U-shaped association between exercise frequency and mortality in individuals with and without DM. However, the frequency of exercise associated with the lowest risk of all-cause mortality was 3-4 times per week (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.65-0.73) in individuals without DM, and 5-6 times per week in those with DM (HR, 0.93; 95% CI, 0.78-1.10).
A moderate frequency of exercise may reduce mortality regardless of the presence or absence of DM; however, when compared to those without the condition, people with DM may need to exercise more often.
本研究旨在分析对于确诊患有和未患有糖尿病（DM）的个体而言，运动频率与全因死亡率之间的关系。
我们分析了国家健康保险服务-国家健康筛查（NHIS-HEALS）队列中 505677 名参与者（53.9%为男性）的数据。研究终点变量为全因死亡率。
在基线时确定了运动频率以及包括年龄、性别、吸烟状况、家庭收入、血压、空腹血糖、体重指数、总胆固醇和 Charlson 合并症指数等协变量。采用 Cox 比例风险回归模型分别评估了运动频率（每周 0、1-2、3-4、5-6 和 7 天）对患有和未患有 DM 的个体的死亡率的影响。我们发现，在患有和未患有 DM 的个体中，运动频率与死亡率之间存在 U 形关联。然而，与全因死亡率风险最低相关的运动频率是每周 3-4 次（风险比 [HR]，0.69；95%置信区间 [CI]，0.65-0.73）在未患有 DM 的个体中，而在患有 DM 的个体中则为每周 5-6 次（HR，0.93；95% CI，0.78-1.10）。
无论是否患有 DM，适度的运动频率都可能降低死亡率；然而，与没有这种疾病的人相比，患有 DM 的人可能需要更频繁地运动。
