口服给药后环丙沙星在人前列腺组织中的浓度。
Concentration of ciprofloxacin in human prostatic tissue after oral administration.
作者信息
Dan M, Golomb J, Gorea A, Braf Z, Berger S A
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):88-9. doi: 10.1128/AAC.30.1.88.
Abstract
Concomitant concentrations of ciprofloxacin in serum, urine, and prostatic tissue were determined in 15 patients after single oral doses of 750 mg. Levels in tissue ranged from 0.6 to 4.18 micrograms/g, and therapeutic concentrations were demonstrable for up to 9 h after administration. The mean ratio of tissue to serum concentration was 0.93 +/- 0.08 (standard error).
摘要
在15名患者单次口服750毫克环丙沙星后，测定了其血清、尿液和前列腺组织中的环丙沙星浓度。组织中的浓度范围为0.6至4.18微克/克，给药后长达9小时可检测到治疗浓度。组织与血清浓度的平均比值为0.93±0.08（标准误差）。
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