Department of Social Medicine, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 08036, Madrid, Spain.
Int J Obes (Lond). 2018 Sep;42(9):1590-1601. doi: 10.1038/s41366-018-0017-1. Epub 2018 Jan 30.
Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits.
We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations.
At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [-0.21 (95% CI: -0.39, -0.03)] and 6 [-0.27 (95% CI:-0.48, -0.05)], waist circumference at age 4 [-1.12 cm (95% CI: -2.10, -0.15)] and 6 [-1.73 cm (95% CI: -3.33, -0.12)], sum of four skinfolds [-2.97 mm (95% CI: -5.70, -0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having "2-3 herpesviruses infections" (versus "0 herpesvirus infections") was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes.
A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.
肥胖的感染源证据正在出现。我们探讨了常见病毒是否与肥胖和代谢特征有关。
我们使用了 Rhea 出生队列中 4 岁和 6 岁随访的横断面（n=674）和前瞻性（n=440）数据。在 4 岁时测量了十种多瘤病毒（BKPyV、JCPyV、KIPyV、WUPyV、HPyV6、HPyV7、TSPyV、MCPyV、HPyV9 和 HPyV10）和四种疱疹病毒（EBV、CMV、HSV-1 和 HSV-2）的 IgG 抗体。4 岁和 6 岁时测量了体重指数、腰围和皮褶厚度。还提供了血清脂质、瘦素和脂联素的数据。使用多变量线性回归模型来探讨关联。
在 4 岁时，多瘤病毒的血清阳性率从 HPyV9 的 21.0%到 HPyV10 的 82.0%不等。EBV、CMV、HSV-1 和 HSV-2 的血清阳性率分别为 53.0%、26.0%、3.6%和 1.5%。BKPyV 血清阳性与 4 岁时的 BMI 标准差评分较低有关[-0.21（95%CI：-0.39，-0.03)]和 6 岁时的 BMI 标准差评分[-0.27（95%CI：-0.48，-0.05)]、4 岁时的腰围[-1.12cm（95%CI：-2.10，-0.15)]和 6 岁时的腰围[-1.73cm（95%CI：-3.33，-0.12)]、4 岁时的四个皮褶总和[-2.97mm（95%CI：-5.70，-0.24)]和 4 岁时的瘦素水平[比值均数，0.83（95%CI：0.70，0.98)]。CMV 血清阳性与 4 岁时的 BMI 标准差评分较高有关[0.28（95%CI：0.11，0.45)]和 6 岁时的 BMI 标准差评分较高[0.24（95%CI：0.03，0.45)]和 6 岁时的四个皮褶总和较高[4.75mm（95%CI：0.67，8.83)]。与“2-3 种疱疹病毒感染”（而非“0 种疱疹病毒感染”）相比，拥有“2-3 种疱疹病毒感染”与 4 岁时的 BMI 标准差评分较高有关[0.32，（95%CI：0.12，0.53)]、腰围[1.22cm（95%CI：0.13，2.31)]和四个皮褶总和较高[3.26mm（95%CI：0.18，6.35)]。多瘤病毒负担与结局无关。
较高的疱疹病毒负担和 CMV 血清阳性与儿童肥胖特征有关。
