儿童期早期接触多瘤病毒和疱疹病毒与肥胖指数和代谢特征有关吗？
Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?
机构信息
Department of Social Medicine, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 08036, Madrid, Spain.
出版信息
Int J Obes (Lond). 2018 Sep;42(9):1590-1601. doi: 10.1038/s41366-018-0017-1. Epub 2018 Jan 30.
BACKGROUND
Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits.
METHODS
We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations.
RESULTS
At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [-0.21 (95% CI: -0.39, -0.03)] and 6 [-0.27 (95% CI:-0.48, -0.05)], waist circumference at age 4 [-1.12 cm (95% CI: -2.10, -0.15)] and 6 [-1.73 cm (95% CI: -3.33, -0.12)], sum of four skinfolds [-2.97 mm (95% CI: -5.70, -0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having "2-3 herpesviruses infections" (versus "0 herpesvirus infections") was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes.
CONCLUSIONS
A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.
背景
肥胖的感染源证据正在出现。我们探讨了常见病毒是否与肥胖和代谢特征有关。
方法
我们使用了 Rhea 出生队列中 4 岁和 6 岁随访的横断面（n=674）和前瞻性（n=440）数据。在 4 岁时测量了十种多瘤病毒（BKPyV、JCPyV、KIPyV、WUPyV、HPyV6、HPyV7、TSPyV、MCPyV、HPyV9 和 HPyV10）和四种疱疹病毒（EBV、CMV、HSV-1 和 HSV-2）的 IgG 抗体。4 岁和 6 岁时测量了体重指数、腰围和皮褶厚度。还提供了血清脂质、瘦素和脂联素的数据。使用多变量线性回归模型来探讨关联。
结果
在 4 岁时，多瘤病毒的血清阳性率从 HPyV9 的 21.0%到 HPyV10 的 82.0%不等。EBV、CMV、HSV-1 和 HSV-2 的血清阳性率分别为 53.0%、26.0%、3.6%和 1.5%。BKPyV 血清阳性与 4 岁时的 BMI 标准差评分较低有关[-0.21（95%CI：-0.39，-0.03)]和 6 岁时的 BMI 标准差评分[-0.27（95%CI：-0.48，-0.05)]、4 岁时的腰围[-1.12cm（95%CI：-2.10，-0.15)]和 6 岁时的腰围[-1.73cm（95%CI：-3.33，-0.12)]、4 岁时的四个皮褶总和[-2.97mm（95%CI：-5.70，-0.24)]和 4 岁时的瘦素水平[比值均数，0.83（95%CI：0.70，0.98)]。CMV 血清阳性与 4 岁时的 BMI 标准差评分较高有关[0.28（95%CI：0.11，0.45)]和 6 岁时的 BMI 标准差评分较高[0.24（95%CI：0.03，0.45)]和 6 岁时的四个皮褶总和较高[4.75mm（95%CI：0.67，8.83)]。与“2-3 种疱疹病毒感染”（而非“0 种疱疹病毒感染”）相比，拥有“2-3 种疱疹病毒感染”与 4 岁时的 BMI 标准差评分较高有关[0.32，（95%CI：0.12，0.53)]、腰围[1.22cm（95%CI：0.13，2.31)]和四个皮褶总和较高[3.26mm（95%CI：0.18，6.35)]。多瘤病毒负担与结局无关。
结论
较高的疱疹病毒负担和 CMV 血清阳性与儿童肥胖特征有关。
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