Health ResearchTx LLC, Trevose, Pennsylvania.
Department of Pediatrics, Naval Medical Center Portsmouth, Portsmouth, Virginia.
Pediatr Diabetes. 2018 Aug;19(5):917-922. doi: 10.1111/pedi.12659. Epub 2018 Mar 8.
To describe the incidence and prevalence of type 1 diabetes among pediatric dependents of the US Department of Defense.
The Military Health System (MHS) data repository was used to identify pediatric patients (≤17 years of age) with type 1 diabetes from January 1, 2007 to December 31, 2012. Annual incidence, annual prevalence and adjusted incidence were calculated and stratified by sex, age group, and region of residence.
Within a 6-year study period from 2007 to 2012, 5616 pediatric patients with type 1 diabetes were identified; 57% male, mean (SD) age of 10.9 (4.2) years. Annual type 1 diabetes incidence (per 100 000 persons) over the 5-year time period ranged from 20.7/100 000 to 21.3/100 000. Incidence for each year was highest in the 10 to 14 years age group and ranged from 30.9/100 000 in 2008 to 35.2/100 000 in 2011. Annual type 1 diabetes prevalence (per 1000 persons) remained stable throughout the study period at 1.5/1000. Adjusted incidence for males was significantly higher compared to females (21.0/100 000 vs 18.1/100 000; P = .001). During the study period, annual incidence remained steady (test for trend, P = .984).
The incidence of type 1 diabetes among children appears to plateau during the study period, suggesting a steady state of type 1 diabetes within this pediatric population. The MHS provides an accurate and up to date look at incidence of type 1 diabetes and may reflect broader trends of incidence of pediatric disease for the United States as a whole.
描述美国国防部未成年子女 1 型糖尿病的发病率和患病率。
利用军事卫生系统(MHS)数据库,从 2007 年 1 月 1 日至 2012 年 12 月 31 日,确定 17 岁以下的 1 型糖尿病患儿。计算每年的发病率、患病率和调整后的发病率,并按性别、年龄组和居住地进行分层。
在 2007 年至 2012 年的 6 年研究期间,共确定了 5616 例 1 型糖尿病患儿;其中男性占 57%,平均(SD)年龄为 10.9(4.2)岁。5 年间每年 1 型糖尿病的发病率(每 10 万人)在 20.7/100000 至 21.3/100000 之间。每年的发病率在 10 至 14 岁年龄组最高,从 2008 年的 30.9/100000 到 2011 年的 35.2/100000。整个研究期间,每年的 1 型糖尿病患病率(每 1000 人)保持稳定,为 1.5/1000。与女性相比,男性的调整发病率显著更高(21.0/100000 比 18.1/100000;P=0.001)。在研究期间,发病率保持稳定(趋势检验,P=0.984)。
在研究期间,儿童 1 型糖尿病的发病率似乎趋于平稳,表明该儿科人群中 1 型糖尿病处于稳定状态。MHS 提供了一个准确和最新的 1 型糖尿病发病率的观察,可能反映了美国整体儿科疾病发病率的更广泛趋势。