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一项实验性白噪声任务能否评估成年健康对照者的精神病易感性?

Can an experimental white noise task assess psychosis vulnerability in adult healthy controls?

作者信息

Gonzalez de Artaza Maider, Catalan Ana, Angosto Virxinia, Valverde Cristina, Bilbao Amaia, van Os Jim, Gonzalez-Torres Miguel Angel

机构信息

Department of Neuroscience, University of the Basque Country, Leioa, Basque Country, Spain.

Department of Psychiatry, Basurto University Hospital, Bilbao, Spain.

出版信息

PLoS One. 2018 Feb 15;13(2):e0192373. doi: 10.1371/journal.pone.0192373. eCollection 2018.

DOI:10.1371/journal.pone.0192373
PMID:29447186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5813930/
Abstract

BACKGROUND

This is an extension of a paper published earlier. We investigated the association between the tendency to detect speech illusion in random noise and levels of positive schizotypy in a sample of 185 adult healthy controls.

MATERIALS AND METHODS

Subclinical positive, negative and depressive symptoms were assessed with the Community Assessment of Psychic Experiences (CAPE); positive and negative schizotypy was assessed with the Structured Interview for Schizotypy-Revised (SIS-R).

RESULTS

Speech illusions were associated with positive schizotypy (OR: 4.139, 95% CI: 1.074-15.938; p = 0.039) but not with negative schizotypy (OR: 1.151, 95% CI: 0.183-7.244; p = 0.881). However, the association of positive schizotypy with speech illusions was no longer significant after adjusting for age, sex and WAIS-III (OR: 2.577, 95% CI: 0.620-10.700; p = 0.192). Speech illusions were not associated with self-reported CAPE measures.

CONCLUSIONS

The association between schizotypy and the tendency to assign meaning in random noise in healthy controls may be mediated by cognitive ability and not constitute an independent trait.

摘要

背景

这是对先前发表论文的扩展。我们在185名成年健康对照样本中,研究了在随机噪声中检测言语错觉的倾向与阳性分裂型人格水平之间的关联。

材料与方法

采用精神体验社区评估量表(CAPE)评估亚临床阳性、阴性和抑郁症状;采用修订版分裂型人格结构化访谈量表(SIS-R)评估阳性和阴性分裂型人格。

结果

言语错觉与阳性分裂型人格相关(比值比:4.139,95%置信区间:1.074 - 15.938;p = 0.039),但与阴性分裂型人格无关(比值比:1.151,95%置信区间:0.183 - 7.244;p = 0.881)。然而,在对年龄、性别和韦氏成人智力量表第三版(WAIS-III)进行校正后,阳性分裂型人格与言语错觉之间的关联不再显著(比值比:2.577,95%置信区间:0.620 - 10.700;p = 0.192)。言语错觉与自我报告的CAPE量表测量结果无关。

结论

在健康对照中,分裂型人格与在随机噪声中赋予意义的倾向之间的关联可能由认知能力介导,并非独立特质。

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本文引用的文献

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PLoS One. 2017 Aug 23;12(8):e0183695. doi: 10.1371/journal.pone.0183695. eCollection 2017.
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Introducing the White Noise task in childhood: associations between speech illusions and psychosis vulnerability.儿童期引入白噪声任务:言语错觉与精神病易感性之间的关联。
Psychol Med. 2016 Oct;46(13):2731-40. doi: 10.1017/S0033291716001112. Epub 2016 Jul 22.
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Psychosis as a transdiagnostic and extended phenotype in the general population.精神病作为普通人群中的一种跨诊断和扩展表型。
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Schizophr Bull. 2016 May;42(3):712-22. doi: 10.1093/schbul/sbv190. Epub 2016 Feb 1.
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PLoS One. 2014 Jul 14;9(7):e102520. doi: 10.1371/journal.pone.0102520. eCollection 2014.
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