Gericke Sebastian, Lübken Tilo, Wolf Diana, Kaiser Martin, Hannig Christian, Speer Karl
Institute of Microbiology, Technische UniCversität Dresden , Zellescher Weg 20b, D-01217 Dresden, Germany.
Clinic of Operative and Pediatric Dentistry, Medical Faculty Carl Gustav Carus, TU Dresden , Fetscherstr. 74, D-01307 Dresden, Germany.
J Agric Food Chem. 2018 Feb 28;66(8):1843-1853. doi: 10.1021/acs.jafc.8b00581. Epub 2018 Feb 20.
Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as markers to differentiate between sage flowers and leaf extracts or to determine the manufacturing technology and storage conditions. Tri-p-coumaroylspermidine can be detected only in flowers and has been described here for Salvia and Lavandula species for the first time. Markers for oxidation processes are the novel compounds salviquinone A and B, which were generated from carnosol by exposure to oxygen. Caffeic acid ethyl ester was established as an indirect marker for the usage of ethanol as extraction solvent. The compounds were identified by LC-QTOF-HRESIMS, LC-MS, NMR, IR, and single-crystal X-ray diffraction after isolation by semipreparative HPLC. Furthermore, sage flower resin showed interesting antibacterial in vitro activities against Gram-positive and Gram-negative bacteria.
丹参属植物的某些部分，如花朵和叶子，目前被用作烹饪香草和一些药用用途。为了区分不同的鼠尾草提取物，有必要分析它们各自的化学成分。它们的特征性化合物可以作为区分鼠尾草花和叶提取物或确定制造工艺和储存条件的标志物。三对香豆酰亚精胺仅能在花朵中检测到，本文首次在丹参属和薰衣草属植物中对此进行了描述。氧化过程的标志物是新化合物鼠尾草醌A和B，它们是由鼠尾草酚暴露于氧气产生的。咖啡酸乙酯被确定为使用乙醇作为提取溶剂的间接标志物。通过半制备高效液相色谱分离后，利用液相色谱-四极杆飞行时间高分辨质谱、液相色谱-质谱、核磁共振、红外光谱和单晶X射线衍射对这些化合物进行了鉴定。此外，鼠尾草花树脂对革兰氏阳性菌和革兰氏阴性菌显示出有趣的体外抗菌活性。
