实验性自身免疫性脑脊髓炎和多发性硬化症中的肌肉肌肽。
Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis.
机构信息
REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan Building A, Diepenbeek, Belgium.
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.
出版信息
Mult Scler Relat Disord. 2018 Apr;21:24-29. doi: 10.1016/j.msard.2018.02.013. Epub 2018 Feb 11.
BACKGROUND
Muscle carnosine is related to contractile function (Ca handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS.
METHODS
Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAE, CON, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE, CON). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured.
RESULTS
EAE muscle carnosine levels were decreased (p < .0001) by ~ 40% to ~ 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03).
CONCLUSION
Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this.
背景
肌肉肌肽与收缩功能（钙处理）和运动引起的酸中毒缓冲有关。由于多发性硬化症（MS）中的这些肌肉功能发生改变，因此了解 MS 中的肌肉肌肽水平很重要。
方法
在动物 MS 模型（EAE，实验性自身免疫性脑脊髓炎）和对照组（CON）中测量比目鱼肌肌肽，在运动训练（EAE，CON，10d，1h/d，24m/min 跑步机跑步）或久坐状态前后（EAE，CON）。测量健康对照组（HC，n=22）和 MS 患者（n=24）的股外侧肌肌肽。
结果
EAE 后 10d 和 17d（分别），无论运动与否（p=0.823），EAE 诱导后肌肉肌肽水平降低（p<0.0001），约为 40%至 64%。同样，MS 患者的肌肉肌肽水平降低（-25%，p=0.03）。
结论
动物 MS 模型和 MS 患者的肌肉肌肽浓度明显降低。EAE 运动疗法并不能恢复这种情况。
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