Lagast H, Dodion P, Klastersky J
J Antimicrob Chemother. 1986 Oct;18(4):513-20. doi: 10.1093/jac/18.4.513.
Teicoplanin (0.2 g) or vancomycin (1 g) were infused over 3 and 50 min respectively to six male volunteers in a cross-over study. Each drug was administered twice at a 14 h interval. The pharmacokinetics of both drugs were accurately described using a two-compartment model. Vancomycin had a shorter half-life (5.8 +/- 1.8 h) compared to teicoplainin (33.2 +/- 5.1 h; P less than 0.001). One hour serum was tested for serum bactericidal activity against ten strains each of Staphylococcus aureus (median serum bactericidal activity 1:16 for teicoplanin; 1:32 for vancomycin), Staph. epidermidis (1:32 for teicoplanin and for vancomycin) and Streptococcus faecalis (1:2 for both drugs). Serum killing rate studies showed a slower rate of killing of Staph. aureus with teicoplanin (less than 1 log10 cfu/ml over 6 h) than with vancomycin (4 log10 cfu/ml over 6 h).
在一项交叉研究中，分别将替考拉宁（0.2克）或万古霉素（1克）在3分钟和50分钟内输注给6名男性志愿者。每种药物以14小时的间隔给药两次。两种药物的药代动力学均使用二室模型进行准确描述。与替考拉宁（33.2±5.1小时；P<0.001）相比，万古霉素的半衰期较短（5.8±1.8小时）。检测给药1小时后的血清对10株金黄色葡萄球菌、表皮葡萄球菌和粪肠球菌的杀菌活性（替考拉宁血清杀菌活性中位数为1:16；万古霉素为1:32；表皮葡萄球菌，替考拉宁和万古霉素均为1:32；粪肠球菌，两种药物均为1:2）。血清杀菌率研究表明，替考拉宁对金黄色葡萄球菌的杀菌速度（6小时内降低不到1 log10 cfu/ml）比万古霉素（6小时内降低4 log10 cfu/ml）慢。
