Department of Chronic Disease, Shanghai Pudong New Area Center for Disease Control and Prevention, Pudong Institute of Preventive Medicine, Fudan University, NO.3039 Zhangyang Road, Pudong New Area, Shanghai, 200136, China.
Department of Chronic Disease, Shanghai Pudong New Area Center for Disease Control and Prevention, Pudong Institute of Preventive Medicine, Fudan University, NO.3039 Zhangyang Road, Pudong New Area, Shanghai, 200136, China.
Sleep Med. 2018 Feb;42:61-67. doi: 10.1016/j.sleep.2017.11.1148. Epub 2018 Jan 9.
Most previous studies on sleep duration and cardio-cerebral vascular disease (CCVD) association have not adequately controlled for many confounders. The current study prospectively examined the association of sleep duration with CCVD prevalence in a Chinese community population; cardiovascular risk factors, chronic diseases, and sleep quality were taken into consideration.
A cross-sectional study conducted in Pudong New Area of Shanghai, China. Through three-stage sampling, 10,657 adults aged ≥15 years were randomly selected. Self-reported sleep duration and CCVD prevalence were obtained using a structured questionnaire. Medical records of the subjects were reviewed by investigators for further confirmation. Relationships between sleep duration and CCVD prevalence were examined using logistic regression models.
Compared to midrange sleep duration (7 h), the multivariate-adjusted OR of CCVD prevalence was 1.550 (95% CI 1.192-2.017) for sleeping 5 h, 1.427 (95% CI 0.983-2.072) for sleeping <5 h. A similar situation also prevailed in coronary heart disease (CHD) prevalence: the multivariate-adjusted OR of stroke prevalence was 2.130 (95% CI 1.338-3.389) for sleeping >9 h. In an analysis stratified by sex, participants with a long sleep duration (>9 h) demonstrated significantly increased prevalence (OR = 3.623, 95% CI 1.862-7.052) for stroke only in men.
The relationship between extreme sleep durations and CCVD were influenced by sex in a Chinese community population. Further studies are needed to investigate the mechanisms of the association between extreme sleep duration and CCVD, as well as sex-specificity in the relationship.
大多数关于睡眠时间与心脑血管疾病（CCVD）关联的既往研究未能充分控制许多混杂因素。本研究前瞻性地考察了睡眠时间与中国社区人群 CCVD 患病率的关联；考虑了心血管危险因素、慢性疾病和睡眠质量。
这是在中国上海浦东新区进行的一项横断面研究。通过三阶段抽样，随机选择了 10657 名年龄≥15 岁的成年人。使用结构化问卷获得睡眠时间和 CCVD 患病率。研究人员查阅了受试者的医疗记录以进一步确认。使用逻辑回归模型检查睡眠时间与 CCVD 患病率之间的关系。
与中等范围睡眠时间（7 小时）相比，睡眠时间为 5 小时的 CCVD 患病率的多变量校正比值比（OR）为 1.550（95%可信区间（CI）1.192-2.017），睡眠时间<5 小时的 OR 为 1.427（95% CI 0.983-2.072）。冠心病（CHD）患病率也存在类似情况：睡眠时间>9 小时的中风患病率的多变量校正 OR 为 2.130（95% CI 1.338-3.389）。在按性别分层的分析中，睡眠时间较长（>9 小时）的参与者中风患病率显著增加（OR=3.623，95% CI 1.862-7.052），仅在男性中如此。
在中国社区人群中，极端睡眠时间与 CCVD 的关系受性别影响。需要进一步研究来探讨极端睡眠时间与 CCVD 之间关联的机制以及这种关联在性别方面的特异性。
