热量限制对抑郁的影响。
Effect of caloric restriction on depression.
机构信息
Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, China.
Department of Physiology, University of Cambridge, Cambridge, UK.
出版信息
J Cell Mol Med. 2018 May;22(5):2528-2535. doi: 10.1111/jcmm.13418. Epub 2018 Feb 21.
Abstract
Recently, most of evidence shows that caloric restriction could induce antidepressant-like effects in animal model of depression. Based on studies of the brain-gut axis, some signal pathways were common between the control of caloric restriction and depression. However, the specific mechanism of the antidepressant-like effects induced by caloric restriction remains unclear. Therefore, in this article, we summarized clinical and experimental studies of caloric restriction on depression. This review may provide a new therapeutic strategy for depression.
摘要
最近，大多数证据表明，热量限制可以在抑郁动物模型中诱导出抗抑郁样作用。基于脑-肠轴的研究，热量限制的控制与抑郁之间存在一些共同的信号通路。然而，热量限制诱导的抗抑郁样作用的确切机制尚不清楚。因此，在本文中，我们总结了热量限制对抑郁症的临床和实验研究。这一综述可能为抑郁症提供一种新的治疗策略。
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