Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
Department of Medical Basic Sciences, Faculty of Applied Medical Sciences, AlBaha University, AlBaha, Saudi Arabia.
Lipids Health Dis. 2021 Sep 21;20(1):112. doi: 10.1186/s12944-021-01537-2.
Increased physical activity is inversely related to the risk to develop cardiovascular disease (CVD). In a recent systematic review, it was reported that CVD patients had an increased cholesterol absorption and a decreased synthesis as compared with control participants. As increased physical activity levels reduce CVD risk, we hypothesized that exercise training will reduce cholesterol absorption and increase endogenous cholesterol synthesis in older overweight and obese men.
A randomized, controlled, crossover trial was performed. Seventeen apparently healthy older overweight and obese men were randomized to start with an aerobic exercise or no-exercise control period for 8 weeks, separated by 12 weeks washout. Fasting serum total cholesterol (TC) and non-cholesterol sterol concentrations were measured at baseline, and after 4 and 8 weeks.
The aerobic exercise program did not affect serum TC concentrations. In addition, exercise did not affect TC-standardized serum concentrations of sitosterol and cholestanol that are markers for cholesterol absorption. However, a trend for reduced TC-standardized campesterol concentrations, which is another validated marker for cholesterol absorption, was observed as compared with control. Lathosterol concentrations, reflecting cholesterol synthesis, did not differ between both periods.
Aerobic exercise training for 8 weeks did not lower serum TC concentrations in older overweight and obese men, but a trend towards a decrease in the cholesterol absorption marker campesterol was found. The cholesterol synthesis marker lathosterol did not change.
posted on www.clinicaltrials.gov as NCT03272061 on 7 September 2017.
增加身体活动与心血管疾病 (CVD) 的发病风险呈负相关。在最近的一项系统评价中，据报道 CVD 患者的胆固醇吸收增加，而合成减少，与对照组相比。由于身体活动水平的增加降低了 CVD 的风险，我们假设运动训练将减少胆固醇吸收并增加老年超重和肥胖男性内源性胆固醇的合成。
进行了一项随机、对照、交叉试验。17 名看似健康的老年超重和肥胖男性被随机分配到有氧运动或无运动对照组，每组持续 8 周，间隔 12 周洗脱期。在基线、4 周和 8 周后测量空腹血清总胆固醇 (TC) 和非胆固醇甾醇浓度。
有氧运动方案不影响血清 TC 浓度。此外，运动也不影响 TC 标准化的血清植物固醇和胆甾烷醇浓度，这是胆固醇吸收的标志物。然而，与对照组相比，TC 标准化菜固醇浓度呈下降趋势，这是另一种经过验证的胆固醇吸收标志物。反映胆固醇合成的羊毛甾醇浓度在两个时期之间没有差异。
8 周的有氧运动训练并未降低老年超重和肥胖男性的血清 TC 浓度，但发现胆固醇吸收标志物菜固醇有下降趋势。胆固醇合成标志物羊毛甾醇没有变化。
于 2017 年 9 月 7 日在 www.clinicaltrials.gov 上注册为 NCT03272061。
