1 Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Watson School of Engineering and Applied Science, Binghamton University, State University of New York (SUNY), Binghamton, NY, USA.
SLAS Technol. 2018 Aug;23(4):301-314. doi: 10.1177/2472630318760515. Epub 2018 Feb 23.
Three-dimensional (3D) bioprinting enables the creation of tissue constructs with heterogeneous compositions and complex architectures. It was initially used for preparing scaffolds for bone tissue engineering. It has recently been adopted to create living tissues, such as cartilage, skin, and heart valve. To facilitate vascularization, hollow channels have been created in the hydrogels by 3D bioprinting. This review discusses the state of the art of the technology, along with a broad range of biomaterials used for 3D bioprinting. It provides an update on recent developments in bioprinting and its applications. 3D bioprinting has profound impacts on biomedical research and industry. It offers a new way to industrialize tissue biofabrication. It has great potential for regenerating tissues and organs to overcome the shortage of organ transplantation.
三维（3D）生物打印技术可用于制造具有异质组成和复杂结构的组织构建体。最初，它被用于制备骨组织工程支架。最近，它已被用于制造活组织，如软骨、皮肤和心脏瓣膜。为了促进血管生成，通过 3D 生物打印在水凝胶中创建了空心通道。本综述讨论了该技术的最新进展，以及用于 3D 生物打印的广泛的生物材料。它提供了生物打印及其应用的最新发展情况。3D 生物打印对生物医学研究和工业有深远的影响。它为组织生物制造的产业化提供了一种新途径。它在再生组织和器官方面具有巨大的潜力，可以克服器官移植的短缺。
