头孢哌酮与大观霉素治疗男性单纯性淋病的对比研究
Comparative study of cefoperazone and spectinomycin for treatment of uncomplicated gonorrhea in men.
作者信息
Hook E W, Judson F N, Verdon M S, Ehret J M, Handsfield H H
出版信息
Antimicrob Agents Chemother. 1986 Oct;30(4):619-21. doi: 10.1128/AAC.30.4.619.
Abstract
Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 microgram/ml. Cefoperazone (1.0 g) and spectinomycin (2.0 g) are comparable for the therapy of anogenital gonorrhea in men.
摘要
对β-内酰胺酶阴性的淋病奈瑟菌感染采用单剂量头孢哌酮（0.5或1.0g）或大观霉素（2.0g）进行治疗。43名接受0.5g头孢哌酮治疗的志愿者中有36名（83%）的肛门生殖器感染得到治愈，61名接受1.0g头孢哌酮治疗的志愿者全部治愈，100名接受大观霉素治疗的志愿者中有99名治愈。242株分离菌的头孢哌酮几何平均最低抑菌浓度为0.028微克/毫升。头孢哌酮（1.0g）和大观霉素（2.0g）在治疗男性肛门生殖器淋病方面疗效相当。
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