使用 [123I]FP-CIT（DaTSCAN）和 SPECT 检测，活跃吸烟者、戒烟者和不吸烟者纹状体多巴胺转运体的可用性无差异。
No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT.
机构信息
Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark.
出版信息
EJNMMI Res. 2013 May 20;3(1):39. doi: 10.1186/2191-219X-3-39.
BACKGROUND
Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminergic neurotransmission and in particular in activating the striatal D2-like receptors. Molecular imaging studies of the relationship between DAT availability/dopamine synthesis capacity and active cigarette smoking have shown conflicting results. Through the collaboration between 13 SPECT centres located in 10 different European countries, a database of FP-CIT-binding in healthy controls was established. We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers.
METHODS
A total of 129 healthy volunteers were included. Subjects were divided into three categories according to past and present tobacco smoking: (1) non-smokers (n = 64), (2) ex-smokers (n = 39) and (3) active smokers (n = 26). For imaging of the DAT availability, we used [123I]FP-CIT (DaTSCAN) and single photon emission computed tomography (SPECT). Data were collected in collaboration between 13 SPECT centres located in 10 different European countries. The striatal measure of DAT availability was analyzed in a multiple regression model with age, SPECT centre and smoking as predictor.
RESULTS
There was no statistically significant difference in DAT availability between the groups of active smokers, ex-smokers and non-smokers (p = 0.34). Further, we could not demonstrate a significant association between striatal DAT and the number of cigarettes per day or total lifetime cigarette packages in smokers and ex-smokers.
CONCLUSION
Our results do not support the hypothesis that large differences in striatal DAT availability are present in smokers compared to ex-smokers and healthy volunteers with no history of smoking.
背景
中脑边缘和黑质纹状体多巴胺能通路在药物的奖赏和条件作用中都起着重要作用。多巴胺转运体（DAT）在调节多巴胺能神经传递中具有核心重要性，特别是在激活纹状体 D2 样受体方面。DAT 可用性/多巴胺合成能力与主动吸烟之间关系的分子影像学研究结果相互矛盾。通过位于 10 个不同欧洲国家的 13 个 SPECT 中心之间的合作，建立了健康对照者中 FP-CIT 结合的数据库。我们使用该数据库来检验假设，即与不吸烟者和戒烟者相比，主动吸烟者的纹状体 DAT 可用性发生变化。
方法
共纳入 129 名健康志愿者。根据过去和现在的吸烟情况，将受试者分为三组：（1）不吸烟者（n = 64），（2）戒烟者（n = 39）和（3）主动吸烟者（n = 26）。对于 DAT 可用性的成像，我们使用[123I]FP-CIT（DaTSCAN）和单光子发射计算机断层扫描（SPECT）。数据由位于 10 个不同欧洲国家的 13 个 SPECT 中心合作收集。在包含年龄、SPECT 中心和吸烟的多变量回归模型中分析纹状体 DAT 可用性。
结果
主动吸烟者、戒烟者和不吸烟者之间的 DAT 可用性无统计学差异（p = 0.34）。此外，我们无法证明吸烟者和戒烟者中纹状体 DAT 与每天吸烟量或总吸烟包数之间存在显著相关性。
结论
我们的结果不支持以下假设，即与戒烟者和无吸烟史的健康志愿者相比，吸烟者的纹状体 DAT 可用性存在较大差异。
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