Laboratory of Molecular Cell Biology, Center for Cancer Research and Department of Medicine C, Sheba Medical Center, Tel Hashomer, Israel.
Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Exp Dermatol. 2018 Jun;27(6):603-610. doi: 10.1111/exd.13520. Epub 2018 Apr 10.
The present review describes in detail the existent data regarding feedback loops between miRNAs and cytokines or growth factors in the psoriatic inflammation. We have chosen to describe the roles of miR-31, miR-21, miR-146a, miR-155, miR-197 and miR-99a in this process. This choice derives from the fact that among around 250 miRNAs being altered in the psoriatic lesion, the comprehensive functional role was described only in those detailed above. In addition, considering the molecular targets and the pathways, which may possibly be regulated by those miRNAs, it seems that they may be chosen as preferred targets for the therapy of psoriasis.
本篇综述详细描述了 miRNA 和细胞因子或生长因子之间在银屑病炎症中反馈环的现有数据。我们选择描述 miR-31、miR-21、miR-146a、miR-155、miR-197 和 miR-99a 在这一过程中的作用。之所以做出这样的选择，是因为在银屑病病变中改变的大约 250 个 miRNA 中，仅对上述 miRNA 全面描述了其功能作用。此外，考虑到这些 miRNA 可能调控的分子靶点和通路，它们似乎可以被选为银屑病治疗的首选靶点。
