Sensaki Sonoko, Sabanayagam Charumati, Chua Sharon, Htoon Hla Myint, Broekman Brit F P, Thiam Daniel Goh Yam, Ngo Cheryl, Saw Seang Mei
Singapore Eye Research Institute and Singapore National Eye Center, Singapore.
Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore.
Asia Pac J Ophthalmol (Phila). 2018 Mar-Apr;7(2):102-108. doi: 10.22608/APO.2017390. Epub 2018 Feb 26.
To investigate the association of sleep duration and quality at 12 months and myopia at 3 years.
Cohort study.
The Growing Up in Singapore Towards Healthy Outcomes (GUSTO) birth cohort recruited pregnant women at 2 major public maternity hospitals (n = 1236). We included 376 children of Chinese, Malay, and Indian ethnicity who had completed caregiver questionnaires on the child's sleep at 12 months of age [Brief Infant Sleep Questionnaire (BISQ)] and also completed cycloplegic autorefraction and eye axial length (AL) measurement at 3 years of age. Data on total sleep duration and number of night wakings were collected by BISQ. Univariable and multivariable regression models adjusting for potential confounders (age, sex, ethnicity, parental myopia, maternal education level, outdoor time, near work, and height) were used.
Thirteen (3.5%) participants were myopic and mean spherical equivalent (SE) was 0.89 diopters (D) (SD 0.88) at 3 years. Total sleep duration and number of night wakings at 12 months were not associated with SE at 3 years (P > 0.05). The total sleep duration (P = 0.07) and number of night wakings (P = 0.49) were not associated with AL in the multivariate model. Total sleep duration in tertile 2 was not associated with AL (P = 0.11) compared with tertile 1. Only total sleep duration in tertile 3 was associated with longer AL (P = 0.006), but there was no association with SE.
Sleep duration and quality at 12 months of age were not associated with refractive error at 3 years.
研究12个月时的睡眠时间和质量与3岁时近视之间的关联。
队列研究。
新加坡成长为健康个体（GUSTO）出生队列在2家主要的公立妇产医院招募了孕妇（n = 1236）。我们纳入了376名华裔、马来裔和印度裔儿童，他们的照料者完成了关于孩子12个月大时睡眠情况的问卷[简短婴儿睡眠问卷（BISQ）]，并且在3岁时完成了睫状肌麻痹验光和眼轴长度（AL）测量。BISQ收集了总睡眠时间和夜间醒来次数的数据。使用了单变量和多变量回归模型，并对潜在混杂因素（年龄、性别、种族、父母近视情况、母亲教育水平、户外活动时间、近距离工作和身高）进行了调整。
13名（3.5%）参与者在3岁时近视，平均球镜等效度（SE）为0.89屈光度（D）（标准差0.88）。12个月时的总睡眠时间和夜间醒来次数与3岁时的SE无关（P > 0.05）。在多变量模型中，总睡眠时间（P = 0.07）和夜间醒来次数（P = 0.49）与AL无关。与第一三分位数相比，第二三分位数的总睡眠时间与AL无关（P = 0.11）。只有第三三分位数的总睡眠时间与较长的AL相关（P = 0.006），但与SE无关。
12个月大时的睡眠时间和质量与3岁时的屈光不正无关。
