,.
Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):37. doi: 10.1167/iovs.61.3.37.
To investigate the relationship between sleep duration and bedtime with myopia progression and axial elongation during a 4-year follow-up in primary school children.
This study included 1887 children (aged 7.09 ± 0.41 years) who had cycloplegic refractions data at baseline and a fourth visit and 2209 children (aged 7.10 ± 0.41 years) for axial length. All children underwent comprehensive ophthalmologic examinations, including cycloplegic refraction and ocular biometry, and standardized questionnaires, including average night-time sleep duration (h/d) and bedtime (time to bed). Myopia was defined as spherical equivalent < -0.5 diopters.
At the last follow-up, the mean myopia progression and axial elongation for all children were -1.89 ± 1.28 diopters and 1.22 ± 0.57 mm. After stratifying the sleep duration into tertile groups, myopia progression and axial elongation were slower in children with highest sleep duration tertile (P = 0.04 and P =0.014) in girls but not in boys, compared with the middle sleep duration tertile. However, after adjusting for potential confounders, no significant association was found for sleep duration with myopia progression and axial elongation for the children (P = 0.255 and P = 0.068), and the association with axial elongation was only of borderline significance in girls (P = 0.045). The bedtime was not associated with myopia progression and axial elongation in the regression analyses (P = 0.538; P = 0.801).
These results show that there was no significant association between sleep duration and bedtime with myopia progression and axial elongation among children. The findings in girls might be related to the earlier onset of puberty.
在一项为期 4 年的小学生随访研究中，调查睡眠时间和就寝时间与近视进展和眼轴伸长的关系。
本研究纳入了 1887 名儿童（年龄为 7.09 ± 0.41 岁），这些儿童在基线和第 4 次就诊时均接受了睫状肌麻痹验光检查，还纳入了 2209 名儿童（年龄为 7.10 ± 0.41 岁）进行眼轴长度检查。所有儿童均接受了全面的眼科检查，包括睫状肌麻痹验光和眼生物测量，并完成了包括平均夜间睡眠时间（小时/天）和就寝时间（上床时间）的标准化问卷。近视定义为等效球镜度数＜-0.5 屈光度。
在最后一次随访时，所有儿童的平均近视进展和眼轴伸长分别为-1.89 ± 1.28 屈光度和 1.22 ± 0.57 毫米。将睡眠时间分为三分位组后，与中睡眠时间组相比，睡眠时间最长的女孩近视进展和眼轴伸长较慢（P = 0.04 和 P = 0.014），但在男孩中没有发现这种差异。然而，在校正潜在混杂因素后，睡眠时间与儿童近视进展和眼轴伸长之间无显著相关性（P = 0.255 和 P = 0.068），且这种相关性在女孩中仅具有边缘显著性（P = 0.045）。回归分析显示，就寝时间与近视进展和眼轴伸长均无相关性（P = 0.538；P = 0.801）。
这些结果表明，睡眠时间和就寝时间与儿童近视进展和眼轴伸长之间无显著关联。女孩的结果可能与青春期更早开始有关。
