Yang Ji Hoon, Yoon Ji Young, Kwon Hyuck Hoon, Min Seonguk, Moon Jungyoon, Suh Dae Hun
Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
Department of Acne, Rosacea, Seborrheic Dermatitis and Hidradenitis Suppurativa Research Laboratory, Seoul National University Hospital, Seoul, South Korea.
Dermatoendocrinol. 2017 Oct 4;9(1):e1356520. doi: 10.1080/19381980.2017.1356520. eCollection 2017.
Despite lots of research on the pathogenesis of acne, the development of new therapeutic agents is still stagnant. Conventional agents which target multiple pathological processes have some serious side effects and this makes seeking new treatment options important for treating acne. As new therapeutic options, researchers are focusing on natural products, synthetic drugs and devices. From natural products, epigallocatechin-3 gallate, lupeol, cannabidiol and Lactobacillus fermented were reported to be possible candidates for novel drugs, targeting multiple pathogenic factors. Synthetic anti- agent, nitric oxide nanoparticles and α-mangostin nanoparticles are shown to be effective in acne treatment. Device or procedural methods such as fractional microneedling radiofrequency, cryolysis, photothermolysis and daylight photodynamic therapy have potential as new treatment options for acne. Further large clinical trials comparing these new treatments with existing agents will be necessary in the future.
尽管对痤疮的发病机制进行了大量研究，但新型治疗药物的研发仍停滞不前。针对多种病理过程的传统药物有一些严重的副作用，这使得寻找新的治疗方案对于治疗痤疮很重要。作为新的治疗选择，研究人员正专注于天然产物、合成药物和设备。在天然产物中，表没食子儿茶素-3-没食子酸酯、羽扇豆醇、大麻二酚和乳酸杆菌发酵产物被报道可能是针对多种致病因素的新型药物候选物。合成抗剂、一氧化氮纳米颗粒和α-山竹黄酮纳米颗粒在痤疮治疗中显示出有效性。诸如分次微针射频、冷冻溶解、光热解和日光光动力疗法等设备或程序方法有潜力成为痤疮的新治疗选择。未来有必要进行进一步的大型临床试验，将这些新疗法与现有药物进行比较。
