Aktas Gulali, Sit Mustafa, Dikbas Oguz, Erkol Hayri, Altinordu Rabia, Erkus Edip, Savli Haluk
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Rev Assoc Med Bras (1992). 2017 Dec;63(12):1065-1068. doi: 10.1590/1806-9282.63.12.1065.
Hashimoto's thyroiditis (HT) is an autoimmune inflammatory disorder. The purpose of this study was to determine the neutrophil-to-lymphocyte ratio (NLR), a novel marker of inflammation, in patients with HT and to compare these values with those from healthy subjects.
A total of 154 participants were included in the study, 90 HT patients and 64 healthy volunteers. Retrospectively, demographic and laboratory data of the subjects were obtained from our institution's database. Patients with active infection, diabetes mellitus, malignancy, other chronic inflammatory diseases, hematologic disorders and patients on aspirin or steroid treatment were excluded from the study. Values for complete blood count (CBC) and serum laboratory parameters of HT patients were the baseline values obtained at the time of HT diagnosis. Control subjects consisted of healthy volunteers who visited our institution for a routine check-up.
Age, gender and CBC parameters were not different between the HT group and the control group; however, the NLR of HT group (2.1 [1.3-5.8]) was significantly higher than the control group (1.9 [0.6-3.3]), p=0.04.
Increased NLR may be useful as an indicator of the presence of HT, especially in complicated cases. NLR is inexpensive and easy to determine. Larger, prospective studies are required to determine its usefulness in assessing diagnostic potential and treatment outcomes in HT patients.
桥本甲状腺炎（HT）是一种自身免疫性炎症性疾病。本研究的目的是测定HT患者炎症的一种新标志物——中性粒细胞与淋巴细胞比值（NLR），并将这些值与健康受试者的值进行比较。
本研究共纳入154名参与者，其中90名HT患者和64名健康志愿者。回顾性地从我们机构的数据库中获取受试者的人口统计学和实验室数据。患有活动性感染、糖尿病、恶性肿瘤、其他慢性炎症性疾病、血液系统疾病的患者以及正在接受阿司匹林或类固醇治疗的患者被排除在研究之外。HT患者的全血细胞计数（CBC）和血清实验室参数值为HT诊断时获得的基线值。对照组由到我们机构进行常规体检的健康志愿者组成。
HT组和对照组之间的年龄、性别和CBC参数没有差异；然而，HT组的NLR（2.1[1.3 - 5.8]）显著高于对照组（1.9[0.6 - 3.3]），p = 0.04。
NLR升高可能作为HT存在的一个指标，尤其是在复杂病例中。NLR价格低廉且易于测定。需要更大规模的前瞻性研究来确定其在评估HT患者诊断潜力和治疗结果方面的有用性。
