BC Materials, Basque Center for Materials, Applications & Nanostructures, Spain.
BC Materials, Basque Center for Materials, Applications & Nanostructures, Spain; Inorganic Chemistry, Department University of Basque Country, 48940, Leioa, Spain.
Colloids Surf B Biointerfaces. 2018 May 1;165:315-324. doi: 10.1016/j.colsurfb.2018.02.031. Epub 2018 Feb 15.
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, FeO nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target αβ integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles.
为了提高用于肿瘤热疗的磁性纳米粒子的选择性，采用“点击”化学方法，用精氨酸-甘氨酸-天冬氨酸（RGD）肽对 FeO 纳米粒子进行了功能化。RGD 肽被连接到之前涂覆的纳米粒子上，以靶向在血管生成癌细胞中过表达的αβ整联蛋白受体。分析了不同的涂层来提高磁性纳米粒子的生物相容性。通过种子生长法合成了单分散且均匀的磁铁矿纳米粒子，并通过 X 射线衍射、热重分析、红外光谱、透射电子显微镜和磁测量对其进行了表征。还研究了纳米粒子的磁热疗效率，并对功能化纳米粒子进行了细胞毒性测定。
