Department of Chemistry , Seoul National University , Seoul 08826 , Korea.
Advanced Institutes of Convergence Technology , Suwon-Si , Gyeonggi-do 16229 , Korea.
Anal Chem. 2018 Apr 3;90(7):4749-4755. doi: 10.1021/acs.analchem.7b05425. Epub 2018 Mar 21.
We suggest an electrochemiluminescence (ECL)-sensing platform driven by ecofriendly, disposable, and miniaturized reverse electrodialysis (RED) patches as an electric power source. The flexible RED patches composed of ion-exchange membranes (IEMs) can produce voltage required for ECL sensing by simply choosing the appropriate number of IEMs and the ratio of salt concentrations. We integrate the RED patch with a bipolar electrode on the microfluidic chip to demonstrate the proof-of-concept, i.e., glucose detection in the range of 0.5-10 mM by observing ECL emissions with naked eyes. The miniaturized RED-powered biosensing system is widely applicable for electrochemical-sensing platforms. This is expected to be a solution for practical availability of battery-free electrochemical sensors for disease diagnosis in developing countries.
我们提出了一种基于环保、一次性和小型化的逆向电渗析（RED）贴片的电致化学发光（ECL）传感平台，作为电源。由离子交换膜（IEM）组成的柔性 RED 贴片可以通过简单地选择适当数量的 IEM 和盐浓度比来产生 ECL 传感所需的电压。我们将 RED 贴片与微流控芯片上的双极电极集成在一起，通过肉眼观察 ECL 发射来验证概念，即通过观察 ECL 发射来检测 0.5-10mM 范围内的葡萄糖。这种小型化的 RED 供电生物传感系统广泛适用于电化学传感平台。这有望为发展中国家的疾病诊断提供无电池电化学传感器的实际应用解决方案。
