Roman Pablo, Abalo Raquel, Marco Eva M, Cardona Diana
Department of Nursing, Physiotherapy and Medicine, University of Almería, Almería.
Department of Nursing, Universitat Jaume I, Castellón.
Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):103-119. doi: 10.1097/FBP.0000000000000385.
In recent years, interest in the relationship between gut microbiota and disease states has grown considerably. Indeed, several strategies have been employed to modify the microbiome through the administration of different diets, by the administration of antibiotics or probiotics, or even by transplantation of feces. In the present manuscript, we focus specifically on the potential application of probiotics, which seem to be a safe strategy, in the management of digestive, pain, and emotional disorders. We present evidence from animal models and human studies, notwithstanding that translation to clinic still deserves further investigation. The microbiome influences gut functions as well as neurological activity by a variety of mechanisms, which are also discussed. The design and performance of larger trials is urgently needed to verify whether these new strategies might be useful not only for the treatment of disorders affecting the gastrointestinal tract but also in the management of emotional and pain disorders not directly related to the gut.
近年来，人们对肠道微生物群与疾病状态之间关系的兴趣显著增加。事实上，已经采用了几种策略来通过给予不同饮食、使用抗生素或益生菌，甚至通过粪便移植来改变微生物组。在本手稿中，我们特别关注益生菌的潜在应用，益生菌似乎是一种安全的策略，可用于管理消化、疼痛和情绪障碍。我们展示了来自动物模型和人体研究的证据，尽管向临床转化仍值得进一步研究。微生物组通过多种机制影响肠道功能以及神经活动，本文也将对此进行讨论。迫切需要设计和开展更大规模的试验，以验证这些新策略是否不仅对治疗影响胃肠道的疾病有用，而且对管理与肠道无直接关系的情绪和疼痛障碍也有用。
